Evidence map›Paper›PMID 40554659›Full record

Trial reportPhysiological reports2025

Irisin and betatrophin responses to 9 h of passive heat exposure: Influence of age, hypertension, and type 2 diabetes.

Joel M Garrett, James J McCormick, Kelli E King, Robert D Meade, Pierre Boulay, Ronald J Sigal, Fergus K O'Connor, Glen P Kenny

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04353076 (Understanding and Managing the Limits of Physiological Tolerance in Heat Vulnerable Canadians During Rest and Physical Exercise), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04353076 nacompletednot on this map

Understanding and Managing the Limits of Physiological Tolerance in Heat Vulnerable Canadians During Rest and Physical Exercise

TypeinterventionalSponsorUniversity of OttawaRan2019 to 2021Enrolled60ConditionsAging, Heat Stress, Physiological StressArmsSimulated heatwave exposure, Simulated heatwave exposure with mid-day cooling
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joel M GarrettSchool of Health Sciences and Social Work, Griffith University, Southport, Queensland, Australia.
James J McCormickHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Kelli E KingHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Robert D MeadeHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Pierre BoulayFaculty of Physical Activity Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada.
Ronald J SigalHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Fergus K O'ConnorSchool of Health Sciences and Social Work, Griffith University, Southport, Queensland, Australia.
Glen P KennyHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.ORCID https://orcid.org/0000-0001-8683-6973

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (IRSC) 399434Gouvernement du Canada | Health Canada (Santé Canada) 4500387992
6 · The paper itself

Abstract

Age- and disease-related metabolic responses to prolonged passive heat exposure are poorly understood. We evaluated serum irisin and betatrophin responses to 9 h of passive heat exposure (40°C, 9% relative humidity) in 19 young adults (19-31 years) and 37 older adults (61-78 years), including those with hypertension (HTN) and type 2 diabetes (T2D). Serum concentrations of irisin and betatrophin were assessed at baseline and at the end of the passive heat exposure using enzyme-linked immunosorbent assays. Generalized linear models were employed to examine changes over time and across subgroups, with fold-change computed as exponentiated coefficients. Younger adults exhibited significantly higher baseline irisin (2.81-fold, p = 0.003) and betatrophin (8.15-fold, p < 0.001) levels compared to older adults. Betatrophin concentrations were further reduced in older adults with HTN (0.55-fold, p = 0.02) and T2D (0.55-fold, p = 0.047). Despite inducing physiological strain, 9 h of passive heat exposure did not alter circulating irisin or betatrophin concentrations in any group (p > 0.66). While passive heat exposure alone does not trigger metabolic hormone responses, lower baseline concentrations may indicate reduced cellular heat tolerance with aging. These findings highlight potential metabolic vulnerabilities in older and heat-sensitive populations and build on previous findings in this series. ClinicalTrials.gov identifier: NCT04353076.

Indexed as

AgingAngiopoietin-like ProteinsDiabetes Mellitus, Type 2FibronectinsHot TemperatureHypertensionPeptide HormonesAdultAgedAge FactorsAngiopoietin-Like Protein 8FemaleHumansMaleMiddle AgedYoung AdultAngiopoietin-Like Protein 8Angiopoietin-like ProteinsANGPTL8 protein, humanFibronectinsFNDC5 protein, humanPeptide Hormonesagingchronic diseaseclimate changeextreme heatheat wavesmetabolic stress

Identifiers

PMID40554659
PMCPMC12186862

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.