Evidence map›Paper›PMID 40555246›Full record

ArticleRenal failure2025

Different patterns of brain iron deposition exist in peritoneal dialysis and hemodialysis patients with cognitive impairment.

Jiamin Liu, Wenbo Yang, Lijun Song, Xianjin Chen, Xiayan Yin, Mingan Li, Xiaoyan Bai, Zhenghan Yang, Zhenchang Wang, Weikang Guo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiamin LiuDepartment of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Wenbo YangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Lijun SongDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Xianjin ChenDepartment of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Xiayan YinDepartment of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Mingan LiDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Xiaoyan BaiDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Zhenghan YangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Zhenchang WangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Weikang GuoDepartment of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Hao WangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Gang WangDepartment of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of cognitive impairment in patients with peritoneal dialysis (PD) and hemodialysis (HD) has been increased, but the specific mechanism is not clear. Disruption of iron homeostasis is associated with cognitive impairment. This study aimed to explore the relationship between brain iron deposition and cognitive impairment in patients with PD and HD by using quantitative susceptibility mapping (QSM).

methodsThe cross-sectional study enrolled 56 PD patients, 66 HD patients, and 56 age-sex matched healthy controls. All participants underwent QSM to measure brain iron content and Montreal Cognitive Assessment (MoCA) to assess cognitive function. In addition, relevant biochemical indicators were collected and analyzed. The ANOVA was used to test for differences in susceptibility value among bilateral caudate nuclei (CAU), thalamus (THA), putamen and pallidum. Pearson correlation analysis was performed to investigate the relationships between susceptibility value and clinical laboratory parameters or MoCA score.

resultsCompared with HC, PD patients showed higher susceptibility value in bilateral CAU and left THA. Compared with HD patients, PD patients showed higher susceptibility value in left THA. PD patients showed a negative correlation between susceptibility value and MoCA score.

conclusionThere are different patterns of brain iron deposition in PD and HD patients. Abnormal brain iron deposition in PD patients may be associated with cognitive impairment.

Indexed as

BrainCognitive DysfunctionIronKidney Failure, ChronicPeritoneal DialysisRenal DialysisAdultAgedCase-Control StudiesCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMental Status and Dementia TestsMiddle AgedIronBrain iron depositioncognitive impairmenthemodialysisperitoneal dialysisquantitative susceptibility mapping

Identifiers

PMID40555246
PMCPMC12893491

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.