Evidence map›Paper›PMID 40555252›Full record

ArticleRenal failure2025

Application of serum STIM1, AOPPS, and urinary NGAL, AGT in the diagnosis of hypertensive nephropathy.

Baohua Li, Chunsheng Wang, Deng Ouyang, Haofeng Xu, Zhile Wu, Xin Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Baohua LiDepartment of General Practice, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Chunsheng WangDepartment of General Practice, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Deng OuyangDepartment of Neurology, The Second People's Hospital of Baiyun, Guangzhou, Guangdong Province, China.
Haofeng XuDepartment of General Practice, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Zhile WuDepartment of Geriatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Xin YangDepartment of General Practice, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aim to explore the diagnostic value of early detection of serum stromal interaction molecule 1 (STIM1), advanced oxidation protein products (AOPPs), urinary neutrophil gelatinase-associated lipocalin (NGAL), and angiotensinogen (AGT) in hypertensive nephropathy (HN).

methodsA retrospective study was conducted on 123 patients with primary hypertension. Based on the diagnostic criteria for HN, patients were divided into the HN group (

resultsThe HN group exhibited higher levels of serum STIM1, AOPPs, and urinary NGAL and AGT than the simple hypertension and control groups. Pearson correlation analysis revealed that serum STIM1 and AOPPs were positively correlated with BUN, UN, and SCr and negatively correlated with eGFR; urinary NGAL and AGT were positively correlated with blood urea nitrogen, uric acid, and serum creatinine and negatively correlated with eGFR (all

conclusionDetection of serum STIM1, AOPPs, and urinary NGAL and AGT has diagnostic value in HN, providing a reference for early diagnosis and timely treatment of HN.

Indexed as

AngiotensinogenHypertension, RenalLipocalin-2Neoplasm ProteinsNephritisStromal Interaction Molecule 1AdultAgedBiomarkersCase-Control StudiesFemaleGlomerular Filtration RateHumansMaleMiddle AgedRetrospective StudiesAngiotensinogenBiomarkersLCN2 protein, humanLipocalin-2Neoplasm ProteinsSTIM1 protein, humanStromal Interaction Molecule 1AGTAOPPsearly detectionHypertensive nephropathyNGALSTIM1

Identifiers

PMID40555252
PMCPMC12893485

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.