ReviewJournal of advanced research2026
Engineering polyphenol-based osteogenic system for bone and cartilage repair: Transplantation, tissue engineering, and organoid.
Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- The messenger ion: magnesium ion coordinates bone marrow mesenchymal stem cells-mediated osteogenesis, migration, and angiogenesis via the PI3K-AKT-mTOR pathway.Stem cell research & therapy · 2026Article
- Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone-Related Diseases.Cell proliferation · 2026Review
- Synergistic 3D-bioprinted scaffold with multi-level adaptability for vascularized bone regeneration via osteogenesis-angiogenesis coupling.Materials today. Bio · 2026Article
- Strontium-baicalein coated β-tricalcium phosphate scaffold enhances diabetic bone regeneration via synergistic ROS scavenging and osteogenic activation.Regenerative biomaterials · 2026Article
- Nanozymes for Bone Regeneration: Mechanistic Insights into Immune and Metabolic Microenvironment Modulation.International journal of nanomedicine · 2026Review
- Biomimetic Nanoparticles for Bone Regeneration: Construction Strategies and Therapeutic Mechanisms.International journal of nanomedicine · 2026Review
- A Nanomedicine Strategy: Spatiotemporally Programmed Delivery of Engineered Exosomes via Smart Scaffolds for Craniofacial Bone Regeneration.International journal of nanomedicine · 2026Review
- ROS-scavenging nanomaterials as emerging tools for bone tissue regeneration: A comprehensive review of recent progress.Acta pharmaceutica Sinica. B · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe human body can spontaneously repair damaged bone tissue and cells; however, external interventions are required to support bone regeneration when the defect exceeds a critical threshold. Bone repair primarily involves the regeneration of both bone and cartilage defects. Natural polyphenols, characterized by polyphenolic hydroxyl structures, readily integrate with other biomaterials to modulate endogenous microenvironment regulation and enhance bone defect repair. AIM OF REVIEW: In this review, we first examine the various sources of natural polyphenols and subsequently discuss their applications in bone and cartilage repair. We then summarize the iterative updates that have evolved through technological innovations, including bone grafting, tissue engineering, and organoids, as well as preclinical and clinical examples of osteogenic systemic therapies. In addition, it highlights the potential of integrating polyphenols into current regenerative medicine technologies. KEY SCIENTIFIC CONCEPTS OF REVIEW: The development of polyphenol-based osteogenic systems has progressed into a new phase, characterized by highly integrated and multicomponent functionality. These systems offer simple and effective strategies for solving various bone defect conditions. However, standardized procedures are still needed to successfully translate polyphenol osteogenic systems into the clinic.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.