Evidence map›Paper›PMID 40555516›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Neural and Behavioral Markers of Negative Symptoms and Cognitive Impairment in Patients with Psychosis.

Raquel van Gool, Mariesa Cay, Hanne van der Heijden, Emma Golden, Amanda Cao, Boyu Ren, Joseph Gonzalez-Heydrich, Ann K Shinn, Jaymin Upadhyay

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raquel van GoolDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115 raquel.vangool@childrens.harvard.edu.ORCID 0000-0001-6486-2388
Mariesa CayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Hanne van der HeijdenDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Emma GoldenDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Amanda CaoDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Boyu RenDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478.
Joseph Gonzalez-HeydrichDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Ann K ShinnDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478.
Jaymin UpadhyayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

Funding

Dissecting Central Mechanisms of Hypoalgesia in SchizophreniaR21MH122967 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI SHINN, ANN KYUNGAH, UPADHYAY, JAYMIN A · 2020 to 2020
$490k
NIMH NIH HHS R21 MH122967
6 · The paper itself

Abstract

Negative and cognitive symptoms impair functioning in patients with psychotic illnesses [i.e., schizophrenia spectrum disorders (SZ) and bipolar I disorder with psychotic features (BD)]. Disruptions in mesocorticolimbic circuitry are hypothesized to underpin negative symptoms and cognitive impairment in patients with psychosis and may also facilitate reward-motivational deficits. In male and female patients with psychosis (

Indexed as

Cognitive DysfunctionPsychotic DisordersAdultFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsNucleus AccumbensRewardWhite MatterYoung Adultbipolar disorderCAINScerebellumcognitionnucleus accumbensrewardschizophrenia

Identifiers

PMID40555516
PMCPMC12311760

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.