Evidence map›Paper›PMID 40556582›Full record

ArticleAdvanced healthcare materials2025

Combination of Polydopamine and Plasma Oxidation to Increase Tissue Integration of Polyurethane-Silicone Copolymers for Cardiovascular Implants.

Sophie Armstrong, Jennifer M Dyson, Lingxiao Zeng, Saeedreza Zeibi Shirejini, John S Forsythe, Shaun D Gregory

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sophie ArmstrongCardioRespiratory Engineering and Technology Laboratory (CREATElab), Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, 3800, Australia.ORCID https://orcid.org/0000-0003-2220-0460
Jennifer M DysonDepartment of Materials Science and Engineering, Monash University, Melbourne, VIC, 3800, Australia.
Lingxiao ZengDepartment of Materials Science and Engineering, Monash University, Melbourne, VIC, 3800, Australia.
Saeedreza Zeibi ShirejiniCardioRespiratory Engineering and Technology Laboratory (CREATElab), Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, 3800, Australia.ORCID https://orcid.org/0000-0003-4403-335X
John S ForsytheDepartment of Materials Science and Engineering, Monash University, Melbourne, VIC, 3800, Australia.ORCID https://orcid.org/0000-0003-2849-229X
Shaun D GregoryCardioRespiratory Engineering and Technology Laboratory (CREATElab), Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, 3800, Australia.ORCID https://orcid.org/0000-0002-5448-1917

Funding

National Health and Medical Research Council 2016995National Heart Foundation of Australia 106675
6 · The paper itself

Abstract

Polyurethane (PU)-silicone co-polymers are increasingly favored in medical applications due to their excellent biostability and durability; however, their intrinsic hydrophobicity limits tissue integration. Polydopamine (PDA) deposition is a widely accepted method for increasing biomaterial surface hydrophilicity, though concentrations and methods vary across published literature. This study investigates the synergistic effects of PDA deposition and plasma oxidation on FDA-approved Elast-Eon E2A (E2A) to enhance cell attachment and wound healing. E2A substrates are treated with a range of plasma oxidation periods and PDA concentrations (0-5 min, 0-0.5 w v-1% respectively). The combination of 0.05 w v-1% PDA and 1-minute oxygen plasma results in the most significant reduction in water contact angle (92to 19°), increase in fibroblast adhesion (33.0-53.2 cells mm

Indexed as

IndolesPolymersPolyurethanesAnimalsBiocompatible MaterialsCell AdhesionFibroblastsHumansOxidation-ReductionSurface PropertiesBiocompatible MaterialsIndolespolydopaminePolymersPolyurethaneselasteonplasma oxidationpolydopamine depositionpolyurethane co‐polymers

Identifiers

PMID40556582
PMCPMC12447051

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.