ArticleFrontiers in neurology2025
Glymphatic system dysfunction in chronic tinnitus patients with sleep disturbance.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lymphatic and Glymphatic Alterations in Auditory Disorders: A Rapid Review-Informed Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
- White Matter Alterations Are More Robust Than Gray Matter Differences in Tinnitus and Hearing Loss: An MRI Study of Military Personnel.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects.Frontiers in aging neuroscience · 2026Review
- Vicious cycle: the bidirectional relationship and pathophysiological mechanisms of tinnitus and sleep disturbance.Frontiers in neurology · 2026Review
- Advances in MRI of glymphatic system dysfunction associated with obstructive sleep apnea and enlarged perivascular spaces.Frontiers in neurology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The neural mechanisms of sleep disturbance associated with chronic tinnitus remains unknown. To investigate this issue, multimodal magnetic resonance imaging (MRI) was used to detect glymphatic system dysfunctions in chronic tinnitus patients with sleep disturbance. Methods: This prospective study included 30 tinnitus with sleep disturbance (TSD), 30 tinnitus with no sleep disturbance (TNSD) and 38 age, sex, and education-matched healthy controls (HCs). All the subjects underwent MRI scans of the glymphatic indexes and clinical assessment. Multimodal MRI indices were used as proxies of glymphatic function and the relationships between the glymphatic function and sleep disturbance were further evaluated. Results: TSD group exhibited significantly higher choroid plexus volume (CPV) and enlarged perivascular spaces (EPVS) values than the HCs group ( Conclusion: Using multimodal MRI approaches, this study provides preliminary evidence for disrupted glymphatic function in chronic tinnitus patients, which may be associated with sleep disturbance. CPV, EPVS, and ALPS could serve as neuroimaging markers and shed new light on neuropathological mechanisms for chronic tinnitus comorbid with sleep disturbance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.