ArticleFrontiers in neurology2025
Impact of transcranial direct current stimulation combined with median nerve stimulation on CRS-R in patients with prolonged disorders of consciousness after cerebral hemorrhage: protocol for a randomized controlled trial.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Non-invasive neuroregulation techniques applied to patients with consciousness disorders: a narrative review.Frontiers in human neuroscience · 2026Review
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Authors and funding
10 authors.
Funding
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Abstract
Background: Prolonged disorders of consciousness (pDoC) resulting from intracerebral hemorrhage (ICH) significantly impair patients' quality of life. This study aims to investigate the therapeutic effects of transcranial direct current stimulation (tDCS) combined with median nerve stimulation (MNS) in patients with pDoC 3-12 months post-ICH. Methods: This prospective, double-blind, randomized controlled trial will enroll 138 eligible patients with pDoC following ICH. Participants will be randomly assigned to three groups of 27 each: (1) tDCS + MNS, (2) sham tDCS + MNS, and (3) tDCS + sham MNS. The intervention will last for 4 weeks, followed by a 6-month follow-up period. The primary outcome measure is the change in the Coma Recovery Scale-Revised (CRS-R) scores. Secondary outcomes include electrophysiological and neuroimaging data. Assessments will be conducted at baseline, after 4 weeks of treatment, and at 2 weeks, 4 weeks, 12 weeks, and 24 weeks post-intervention. Discussion: The strengths of this study include the combined intervention approach of tDCS and MNS, as well as comprehensive outcome measures. This intervention may promote consciousness recovery through multiple mechanisms, including enhanced neuroplasticity and modulation of brain networks. This study aims to provide a novel approach for consciousness-promoting treatment in pDoC, potentially improving patient prognosis and quality of life. Clinical trial registration: https://www.chictr.org.cn/showproj.html?proj=203618, identifier ChiCTR2300075190.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.