ArticleACS measurement science au2025
Subcellular Mechanical Imaging of Erythrocytes with Optically Correlated Scanning Ion Conductance Microscopy.
Article in ACS measurement science au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Live-Cell SICM Imaging: An Introductory Guide for New Users.Analytical chemistry · 2026Article
- Observation of Acetylcholine Secretion on Living Glioblastoma Cells.ACS measurement science au · 2026Article
- Applications of Nanopipettes in Scanning Ion Conductance Microscopy for High-Spatial-Resolution Topographic Imaging and Sensing in Single Cells.ACS measurement science au · 2026Review
- A Look inside a Flexible Open-Source Scanning Electrochemical Probe Microscope.ACS electrochemistry · 2026Article
- Microfluidic Determination of Cell-Derived ATP and Single Cell Pressure Mapping Confirms Benefits of Normoglycemic Stored Red Blood Cells.ACS measurement science au · 2025Article
- Construction of a Scanning Ion-Conductance Microscope for Tip-Enhanced Raman Spectroscopy.Analytical chemistry · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We report mapping the mechanical properties of human red blood cells at submicron scales. Mapping is achieved via a new approach to scanning ion conductance microscopy correlated with optical microscopy. A three-point calibration and affine transformation are utilized to correlate pixel locations registered in optical images with pipette position, which facilitates initial targeting and subsequent tracking and analysis of red blood cells. By recording the response of pipette approach curves and sample compliance at each approach, maps of the Young's modulus of samples and pipette indentation are recorded at subcellular spatial resolution. Comparison of normal and diamide-treated red blood cells shows a significant increase in cell stiffness and a concomitant decrease in deformability, clearly demonstrating the quantitative abilities of the correlative approach taken here for stiffness measurements of intact cellular samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.