ArticleOpen veterinary journal2025
Fertility failure of vulvar and vaginal squamous cell carcinoma in dairy cows associated with reproductive hormonal disturbance, vulvar and vaginal hyperplasia, acute phase protein production, and histopathological changes.
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The majority of neoplasms affect bovine species, and the most common are squamous cell carcinomas (SCCs) in sheep, goats, and cattle. Neoplasm of the vulva and vagina in dairy cattle undergo widespread in dairy herds. Aim: This study aimed to examine the effects of vulvar and vaginal squamous cell carcinoma (VSCC) on the fertility of dairy cows by investigating changes in reproductive hormones as well as vaginal and vulvar tissue. In addition, acute phase protein (APP) production and histopathological changes were also investigated to evaluate their relationship with tumor development and to assess their diagnostic and prognostic value. Methods: Twenty dairy cows were divided into two equal groups: the diseased group, which suffered from vulvar and vaginal squamous cell carcinoma and known as vulvar and vaginal squamous cell carcinoma group (VSCCG), and the healthy group, which served as the normal control group (NCG). Sera were used to evaluate reproductive hormones (progesterone, estrogen, follicle-stimulating hormone, and luteinizing hormone) and acute phase proteins (APPs), such as serum amyloid A (SAA), haptoglobin (Hp), ceruloplasmin (Cp), C-reactive protein (CRP), and creatine kinase (CK). Histopathological examination and immunohistochemical investigations [S100, vimentin and alpha-smooth muscle actin (α-SMA)] of the vaginal tissue were performed. Results: Results revealed that VSCCG exhibits a significant increase in the levels of reproductive hormones compared with NCG. Investigation of APPs revealed a significant increase in the levels of SAA, Hp, Cp, CRP, and CK in diseased cows compared to healthy cows. Histological investigation revealed that the vaginal mucosa from SCC cows indicated the presence of dense squamous epithelial cell invasion and variant keratin pearls. The neoplastic cells appeared as large, polyhedral cells with hyperchromatic nuclei. Additionally, koilocytic and atypical mitosis were noted. Immunohistochemical analysis of S100, vimentin, and α-SMA shows very strong positive reactions in diseased cows. Conclusion: The present study revealed that VSCC is associated with reproductive hormonal disturbance and a rise in APP production, which are responsible for fertility failure and may even lead to sudden death.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.