ReviewFrontiers in immunology2025
Research progress on composite nerve guidance conduits with immune-regulatory functions.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- A diameter-adaptive, suture-free conduit with magnetoelectric responsiveness promotes peripheral nerve regeneration.Bioactive materials · 2026Article
- Localized Tacrolimus Delivery for Peripheral Nerve Regeneration: Molecular Mechanisms, Biomaterial Platforms, and Translational Strategies.International journal of molecular sciences · 2026Review
- Low-Frequency Electrical Stimulation Optimizes Neurotrophic and Neuroimmune Signaling in Bisvinyl Sulfonemethyl-Based Nerve Guidance Conduits.International journal of molecular sciences · 2026Article
- Preparation and experimental evaluation of degradable esophageal stents based on novel polylactic acid materials.Frontiers in bioengineering and biotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral nerve injury (PNI) has emerged as a critical clinical challenge due to its high disability rate and socioeconomic burden. Traditional autologous nerve grafting, limited by donor shortages and risks of secondary surgeries, has driven tissue-engineered nerve conduits to become a research hotspot. This review systematically summarizes recent advances in immunomodulatory nerve conduits, focusing on the biological properties, degradation mechanisms, and pivotal roles of natural materials (e.g., collagen, chitosan, silk fibroin) and synthetic materials (e.g., poly (lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), and polycaprolactone (PCL) in regulating macrophage polarization. The potential of composite materials to synergistically optimize mechanical performance and bioactivity of nerve conduits is also discussed. Furthermore, this review envisions future trends in nerve conduits, including the integration of 4D printing, smart-responsive systems, and personalized designs to overcome current therapeutic limitations. By integrating multidisciplinary perspectives from materials science, immunology, and regenerative medicine, this review aims to provide innovative theoretical frameworks and technical pathways for efficiently repairing PNI, advancing clinical translation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.