ReviewJournal of current ophthalmology
Persistent Diabetic Macular Edema: A Comprehensive Review of Current Treatments and Emerging Therapeutic Options.
Review in Journal of current ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To comprehensively review and evaluate the therapeutic strategies for persistent diabetic macular edema (DME), with a particular emphasis on established treatments. Furthermore, the study explores emerging and innovative therapeutic options. Methods: A nonsystematic search was carried out using PubMed, Cochrane, Medline, and Google Scholar databases with the keywords "macular edema", "persistent", "diabetic", "therapeutic", and "emerging". We specifically looked for experimental studies, randomized clinical trials, and retrospective and prospective studies without limiting the search timeframe for the articles up to December 2023. Results: This review delineates a comprehensive array of treatment modalities for persistent DME, encompassing anti-vascular endothelial growth factor (anti-VEGF) switching, corticosteroids, laser therapies, combination therapy, and surgical approaches. Additionally, emerging treatments were explored, featuring novel anti-VEGF agents, innovative surgical techniques, as well as inhibitors targeting Angiopoietin-2 and the Kallikrein-Kinin System. Conclusions: It is important to employ personalized and evidence-based approaches in addressing persistent DME. The ongoing advancement in treatment paradigms will play a crucial role in the continual evolution of DME management.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.