Evidence map›Paper›PMID 40557469›Full record

ArticleAging cell2025

CD38-Targeting Peptide Vaccine Ameliorates Aging-Associated Phenotypes in Mice.

Shangcheng Yu, Zhiqiang Li, Yuxiang Tang, Yuling Chen, Yingying Ma, Kunlin Du, Zhaoyun Zong, Kangze Feng, Yali Wei, Limeng Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shangcheng YuMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China.ORCID 0000-0002-2305-4744
Zhiqiang LiMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China.ORCID 0000-0003-3199-6974
Yuxiang TangMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China.
Yuling ChenMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China.
Yingying MaMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China.
Kunlin DuMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China.ORCID 0009-0009-2591-8794
Zhaoyun ZongMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China.
Kangze FengMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China.
Yali WeiDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Limeng ChenDepartment of Nephrology, Peking Union Medical College Hospital, Beijing, China.
Haiteng DengMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China.ORCID 0000-0001-9496-1280

Funding

Beijing Municipal Natural Science Foundation IS24040National Key Research and Development Program of China 2021YFA1302601National Natural Science Foundation of China 82172556National Natural Science Foundation of China T2293763
6 · The paper itself

Abstract

Antiaging vaccines have recently been found to elicit long-term benefits in slowing the aging process. Meanwhile, high CD38 expression in organs is an aging characteristic contributing to a decreased NAD

Indexed as

ADP-ribosyl Cyclase 1AgingMembrane GlycoproteinsVaccines, SubunitAnimalsMiceMice, Inbred C57BLPhenotypeProtein Subunit VaccinesADP-ribosyl Cyclase 1Membrane GlycoproteinsProtein Subunit VaccinesVaccines, SubunitagingCD38peptidevaccine

Identifiers

PMID40557469
PMCPMC12419845

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.