Evidence map›Paper›PMID 40558085›Full record

ArticlemBio2025

Bacterial type IV secretion system induces specific and nonspecific protective immunity.

Fernanda V S Castanheira, Marcelo S F Pereira, Marco A Ataide, Danielle P A Mascarenhas, Rhanoica O Guerra, Gustavo F S Quirino, Fausto Almeida, Dario S Zamboni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fernanda V S Castanheira *Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Marcelo S F Pereira *Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Marco A AtaideDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Danielle P A MascarenhasDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Rhanoica O GuerraDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Gustavo F S QuirinoDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Fausto AlmeidaDepartamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Dario S ZamboniDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID 0000-0002-7856-7512

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 401577/2014-7,303021/2020-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/11342-6,2013/08216-2
6 · The paper itself

Abstract

Pathogenic microbes trigger rapid and robust innate immune responses that effectively restrict pathogen replication and promote long-lasting adaptive immunity. The differential recognition of pathogenic versus non-pathogenic microbes occurs through the detection of host cell damage or pathogen molecules secreted via virulence factors, such as specialized bacterial secretion systems. Despite the well-established role of bacterial secretion systems in pathogenesis and subversion of host cell responses, their impact on immune activation remains largely unexplored. Here, we used IMPORTANCE: Understanding how bacteria interact with the immune system is crucial for developing better treatments and vaccines. This study reveals that a bacterial secretion system, the type IV secretion system (T4SS) of

Indexed as

CoinfectionHost-Pathogen InteractionsInnate Immunity RecognitionType IV Secretion SystemsVirulence FactorsAnimalsBacterial VaccinesCryptococcus neoformansDisease Models, AnimalFemaleLegionella longbeachaeLegionella pneumophilaLegionnaires' DiseaseMaleMiceMice, Inbred C57BLBacterial VaccinesType IV Secretion SystemsVirulence Factorsimmunityinfectioninnate instruction of adaptive immunityLegionella pneumophilatype IV secretion system

Identifiers

PMID40558085
PMCPMC12345216

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.