ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Spatiotemporal Adaptations-Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- [Skin organoids: an emerging platform from three-dimensional construction to regenerative application].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- Spatiotemporal decoding of skin biology: development, aging, disease, and regeneration.Burns & trauma · 2026Article
- Spatiotemporal Adaptations-Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
The evolutionary adaptation of skin repair drives sequential regenerative phases: epidermal proliferation rapidly restores barrier function, followed by dermal reconstruction through extracellular matrix remodeling to establish structural support, yet the molecular coordination of this spatiotemporal program remains unclear. While the endocrine system is crucial in modulating wound repair, the critical hormone receptors orchestrating tissue-layer-specific responses are unidentified. Here, bulk and single-cell RNA sequencing, spatial transcriptomics, and in vivo/in vitro analyses in mouse models of hyperthyroidism and hypothyroidism, as well as wound and skin organoid models, are employed to identify the thyroid hormone receptor Thra as a key regulator of phase-coupled regeneration through two distinct yet coordinated mechanisms. In the initial phase, epidermal Thra activates glutathione metabolism via Gamma-Glutamylcyclotransferase (GGCT), driving keratin filament assembly to accelerate reepithelialization. In the subsequent phase, dermal Thra mediates the Serum Amyloid A3 (SAA3)-Fibronectin 1 (FN1) interaction, establishing angiogenic niches essential for matrix maturation. Using the self-assembled epidermis-dermis dynamic skin organoid model, Thra's role in simulating the wound healing process is further confirmed. This study highlights the essential role of spatiotemporal adaptability in wound repair using Thra as a paradigm and provides insights for developing clinical strategies to enhance skin wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.