Evidence mapPaperPMID 40559641Full record

ArticleMarine drugs2025

The Alkaloid Caulerpin Exhibits Potent and Selective Anti-Inflammatory Activity Through Interaction with the Glucocorticoid Receptor.

Jônatas Sousa Pires Dos Santos, Dahara Keyse Carvalho Silva, Vanessa da Silva Oliveira, Sergio Santos Silva Junior, Edivaldo Dos Santos Rodrigues, Claudia Valeria Campos de Souza, Sabrina Teixeira Martinez, Osvaldo Andrade Santos-Filho, Cássio Santana Meira, Milena Botelho Pereira Soares

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jônatas Sousa Pires Dos SantosDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 40020-000, Brazil.
Dahara Keyse Carvalho SilvaGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, Brazil.
Vanessa da Silva OliveiraDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 40020-000, Brazil.
Sergio Santos Silva JuniorGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, Brazil.ORCID 0009-0003-5074-4016
Edivaldo Dos Santos RodriguesLaboratory of Molecular Modeling and Computational Structural Biology, Walter Mors Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, Brazil.
Claudia Valeria Campos de SouzaLaboratory of Molecular Modeling and Computational Structural Biology, Walter Mors Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, Brazil.
Sabrina Teixeira MartinezInstitute of Innovation in Advanced Health Systems (ISI SAS), University SENAI/CIMATEC, Salvador 41650-010, Brazil.
Osvaldo Andrade Santos-FilhoLaboratory of Molecular Modeling and Computational Structural Biology, Walter Mors Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, Brazil.ORCID 0000-0001-7407-158X
Cássio Santana MeiraDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 40020-000, Brazil.ORCID 0000-0002-7578-3615
Milena Botelho Pereira SoaresGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, Brazil.

Funding

CAPES 001FAPESB PPP0027/2024
6 · The paper itself

Abstract

Inflammation plays a central role in various pathological conditions, necessitating the search for safer and more effective anti-inflammatory agents. This study investigates the anti-inflammatory activity of caulerpin, a bisindolic alkaloid isolated from

Indexed as

AlkaloidsAnti-Inflammatory AgentsReceptors, GlucocorticoidAnimalsDisease Models, AnimalInflammationLipopolysaccharidesMacrophagesMaleMiceMolecular Docking SimulationMolecular Dynamics SimulationRAW 264.7 CellsShock, SepticAlkaloidsAnti-Inflammatory AgentsLipopolysaccharidesReceptors, Glucocorticoidanti-inflammatory activitycaulerpinglucocorticoid receptormacrophages

Identifiers

PMID40559641
PMCPMC12194734

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.