Evidence map›Paper›PMID 40559663›Full record

ArticleMarine drugs2025

Exploring the Catalytic Mechanisms of a Newly Identified Salt-Activated Alginate Lyase from

Xiaoyan Zhuang, Chao Jiao, Zewang Guo, Qiong Xiao, Jun Chen, Fuquan Chen, Qiuming Yang, Yi Ru, Huifen Weng, Siyuan Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoyan ZhuangCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361005, China.
Chao JiaoCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361005, China.
Zewang GuoCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361005, China.
Qiong XiaoCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361005, China.ORCID 0000-0001-9470-3927
Jun ChenCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361005, China.
Fuquan ChenCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361005, China.
Qiuming YangCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361005, China.
Yi RuCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361005, China.
Huifen WengCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361005, China.
Siyuan WangSuzhou Institute for Drug Control, Suzhou 215000, China.
Anfeng XiaoCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361005, China.ORCID 0000-0003-0327-8860
Yonghui ZhangCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361005, China.ORCID 0000-0002-7313-4259

Funding

Fujian Province Natural Science Foundation of China 2022J01331National Natural Science Foundation of China 22278173, 32301252Xiamen Natural Science Foundation of China 3502Z202473055, 3502Z20227054
6 · The paper itself

Abstract

Alginate lyases are critical enzymes in hydrolyzing alginate into alginate oligosaccharides (AOS), which are bioactive compounds known for their antioxidant properties and ability to lower serum glucose and lipid concentrations. However, elucidating catalytic mechanisms and discovering enzymes with enhanced catalytic efficiency remain long-term challenges. Here, we report AlgL2491, a novel bifunctional and cold-adapted alginate lyase from

Indexed as

Polysaccharide-LyasesPseudoalteromonasAlginatesAntioxidantsBacterial ProteinsCatalysisFree Radical ScavengersHydrogen-Ion ConcentrationHydrolysisMolecular Dynamics SimulationOligosaccharidesSodium ChlorideAlginatesAntioxidantsBacterial ProteinsFree Radical ScavengersOligosaccharidespoly(beta-D-mannuronate) lyasePolysaccharide-LyasesSodium Chloridealginate lyaseantioxidant activityheterologous expressionsalt-activated

Identifiers

PMID40559663
PMCPMC12193947

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.