Evidence map›Paper›PMID 40559664›Full record

ReviewMarine drugs2025

Bioactive Polyketides from

Noemi Russo, Giulia Quaini, Marcello Ziaco, Daniela Castiglia, Alessandra Ruggiero, Vincenzo D'Amelia, Concetta Di Napoli, Sergio Esposito, Angelo Fontana, Genoveffa Nuzzo and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Noemi RussoDepartment of Biology, University of Naples Federico II, Via Cintia 21, 80126 Naples, Italy.ORCID 0009-0007-1239-2602
Giulia QuainiDepartment of Biology, University of Naples Federico II, Via Cintia 21, 80126 Naples, Italy.ORCID 0009-0000-7426-6846
Marcello ZiacoBio-Organic Chemistry Unit, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, 80078 Pozzuoli, Italy.ORCID 0000-0002-0054-779X
Daniela CastigliaBio-Organic Chemistry Unit, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, 80078 Pozzuoli, Italy.ORCID 0000-0002-9794-8644
Alessandra RuggieroInstitute of Bioscience and Bioresources, National Research Council, Via Università 133, 80055 Portici, Italy.
Vincenzo D'AmeliaDepartment of Agronomy, University of Naples Federico II, Via Università 100, 80055 Portici, Italy.ORCID 0000-0002-8548-6825
Concetta Di NapoliDepartment of Biology, University of Naples Federico II, Via Cintia 21, 80126 Naples, Italy.
Sergio EspositoDepartment of Biology, University of Naples Federico II, Via Cintia 21, 80126 Naples, Italy.
Angelo FontanaDepartment of Biology, University of Naples Federico II, Via Cintia 21, 80126 Naples, Italy.
Genoveffa NuzzoBio-Organic Chemistry Unit, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
Simone LandiDepartment of Biology, University of Naples Federico II, Via Cintia 21, 80126 Naples, Italy.ORCID 0000-0002-1647-6121

Funding

PRIN-PNRR2022 "Molecular integration, interaction and reconstruction of biosynthetic pathway of polyketide synthase from photosynthetic organisms" P2022XFYRS
6 · The paper itself

Abstract

Polyketides (PKs) are a widespread class of secondary metabolites with recognised pharmacological properties. These molecules are abundantly produced in the marine environment, especially by dinoflagellate-photosynthetic organisms able to produce several PKs, including neurotoxins, cytotoxins, and immunomodulating agents. The biosynthesis of these compounds is driven by a conserved enzymatic process involving polyketide synthase complexes. Different genera of dinoflagellates produce PKs. Among them, dinoflagellates of the genus

Indexed as

DinoflagellidaPolyketidesAnimalsAquatic OrganismsBiosynthetic PathwaysBiotechnologyHumansPolyketide SynthasesPolyketidesPolyketide SynthasesAmphidinium spp.dinoflagellatesmarine natural productspolyketidespolyketide synthases

Identifiers

PMID40559664
PMCPMC12194139

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.