Evidence map›Paper›PMID 40559872›Full record

ArticleToxins2025

CYP1B1 Knockout in a Bovine Hepatocyte-like Cell Line (BFH12) Unveils Its Role in Liver Homeostasis and Aflatoxin B1-Induced Hepatotoxicity.

Silvia Iori, Ludovica Montanucci, Caterina D'Onofrio, Maija Lahtela-Kakkonen, Lorena Lucatello, Anisa Bardhi, Andrea Barbarossa, Francesca Capolongo, Anna Zaghini, Marianna Pauletto and 2 more

Abstract read
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Silvia IoriDepartment of Comparative Biomedicine and Food Science, University of Padua, 35020 Padua, Italy.
Ludovica MontanucciDepartment of Neurology, McGovern Medical School, UTHealth-University of Texas Health Science Centre at Houston, Houston, TX 77030, USA.ORCID 0000-0003-2375-7359
Caterina D'OnofrioDepartment of Comparative Biomedicine and Food Science, University of Padua, 35020 Padua, Italy.
Maija Lahtela-KakkonenSchool of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland.
Lorena LucatelloDepartment of Comparative Biomedicine and Food Science, University of Padua, 35020 Padua, Italy.
Anisa BardhiDepartment of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna, Via Tolara di Sopra 50, Ozzano dell'Emilia, 40064 Bologna, Italy.ORCID 0000-0002-2012-2852
Andrea BarbarossaDepartment of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna, Via Tolara di Sopra 50, Ozzano dell'Emilia, 40064 Bologna, Italy.ORCID 0000-0002-7742-4229
Francesca CapolongoDepartment of Comparative Biomedicine and Food Science, University of Padua, 35020 Padua, Italy.ORCID 0000-0002-2848-0582
Anna ZaghiniDepartment of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna, Via Tolara di Sopra 50, Ozzano dell'Emilia, 40064 Bologna, Italy.ORCID 0000-0002-1108-0259
Marianna PaulettoDepartment of Comparative Biomedicine and Food Science, University of Padua, 35020 Padua, Italy.ORCID 0000-0002-2424-7484
Mauro DacastoDepartment of Comparative Biomedicine and Food Science, University of Padua, 35020 Padua, Italy.ORCID 0000-0002-3637-5643
Mery GiantinDepartment of Comparative Biomedicine and Food Science, University of Padua, 35020 Padua, Italy.ORCID 0000-0003-0015-3800

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CYP1B1 is a key enzyme involved in xenobiotic and endogenous metabolism, yet its physiological role in bovine liver homeostasis remains unclear. In this study, we generated a

Indexed as

Aflatoxin B1Chemical and Drug Induced Liver InjuryCytochrome P-450 CYP1B1HepatocytesLiverAnimalsCattleCell LineGene Knockout TechniquesHomeostasisAflatoxin B1Cytochrome P-450 CYP1B1AFB1bovineCRISPR/Cas9CYP1B1livermolecular docking

Identifiers

PMID40559872
PMCPMC12197428

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.