Evidence mapPaperPMID 40559943Full record

ReviewToxics2025

Clinical Impact of Vaping.

Francesco Petrella, Paola Faverio, Andrea Cara, Enrico Mario Cassina, Lidia Libretti, Sara Lo Torto, Emanuele Pirondini, Federico Raveglia, Francesca Spinelli, Antonio Tuoro and 2 more

Abstract readReview
In one paragraph

Review in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Toxicity and Appeal of Flavoured E-Cigarettes and Flavour Ban Outcomes: A Narrative Review.International journal of environmental research and public health · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesco PetrellaDepartment of Thoracic Surgery Fondazione IRCCS san Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0001-5945-1576
Paola FaverioDepartment of Respiratory Diseases Fondazione IRCCS san Gerardo dei Tintori, Monza (MB), Italy and University of Milano Bicocca, 20126 Milan, Italy.ORCID 0000-0002-0360-1237
Andrea CaraDepartment of Thoracic Surgery Fondazione IRCCS san Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0002-6314-8518
Enrico Mario CassinaDepartment of Thoracic Surgery Fondazione IRCCS san Gerardo dei Tintori, 20900 Monza, Italy.
Lidia LibrettiDepartment of Thoracic Surgery Fondazione IRCCS san Gerardo dei Tintori, 20900 Monza, Italy.
Sara Lo TortoDepartment of Thoracic Surgery Fondazione IRCCS san Gerardo dei Tintori, 20900 Monza, Italy.
Emanuele PirondiniDepartment of Thoracic Surgery Fondazione IRCCS san Gerardo dei Tintori, 20900 Monza, Italy.
Federico RavegliaDepartment of Thoracic Surgery Fondazione IRCCS san Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0009-0005-3681-5396
Francesca SpinelliDepartment of Thoracic Surgery Fondazione IRCCS san Gerardo dei Tintori, 20900 Monza, Italy.
Antonio TuoroDepartment of Thoracic Surgery Fondazione IRCCS san Gerardo dei Tintori, 20900 Monza, Italy.
Elisa PergerDepartment of Respiratory Diseases Fondazione IRCCS san Gerardo dei Tintori, Monza (MB), Italy and University of Milano Bicocca, 20126 Milan, Italy.
Fabrizio LuppiDepartment of Respiratory Diseases Fondazione IRCCS san Gerardo dei Tintori, Monza (MB), Italy and University of Milano Bicocca, 20126 Milan, Italy.ORCID 0000-0001-5775-5947

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term 'vaping' refers to the use of electronic cigarettes or other devices to inhale a variety of heated and aerosolized substances. Vaping has been promoted as a less harmful and potentially oncogenic alternative to nicotine cigarettes, particularly to help heavy smokers quit. While vaping products do not produce the same carcinogenic substances-such as polycyclic aromatic hydrocarbons-generated by the combustion of tobacco, and while their fluids lack tobacco-related carcinogens like nitrosamines, it is now well established that they still generate harmful and potentially oncogenic byproducts. Several mechanisms have been proposed to explain the potential oncogenic effects of vaping fluids, including direct chemical action, epithelial-mesenchymal transition induction, redox stress, mitochondrial toxicity, and DNA damage. In addition to cancer risk, there have been reports of adverse effects on cardiovascular health, reproductive function, and non-oncologic lung injuries. These include exogenous lipoid pneumonia, diffuse alveolar hemorrhage with proven alveolar injury, and vaping-associated bronchiolitis obliterans. The aim of this review is to examine vaping devices, their potential role in lung carcinogenesis, vaping-associated lung injury, and other clinical implications, including impacts on cardiovascular, cerebrovascular, and respiratory diseases, and also pregnancy and fetus health.

Indexed as

asthmachronic obstructive pulmonary disease (COPD)electronic cigarettee-smokinglung cancervaping

Identifiers

PMID40559943
PMCPMC12197008

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.