ArticleMolecular biology reports2025
Expression patterns and clinical relevance of H19, miR-181a-3p, and TGF-β in ascending aortic aneurysms: a comparative analysis of human aortic tissue.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAscending aortic aneurysms (AsAA) are progressive dilations of the aortic wall associated with pathological remodeling. Non-coding RNAs, including lncRNA H19 and miR-181a-3p, regulate vascular remodeling and inflammation, partly through modulation of the TGF-β signaling pathway. METHODS AND
resultsThis study compared the expression of H19, miR-181a-3p, and TGF-β in aortic tissues from 48 patients undergoing AsAA or multivessel coronary artery bypass grafting (mCABG). Aortic tissue samples were collected, and RNA was extracted for quantitative real-time PCR analysis. MiR-181a-3p expression was significantly lower in the AsAA group compared to the mCABG group (p = 0.004), while TGF-β expression was higher (p = 0.022). When adjusted for DM, the difference in TGF-β expression became insignificant and H19 expression showed no significant difference between AsAA and mCABG groups.
conclusionsThe decreased expression of miR-181a-3p in AsAA suggests its potential as a biomarker. Further studies are needed to explore its role in AsAA pathophysiology.
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