Evidence map›Paper›PMID 40560292›Full record

ReviewCurrent heart failure reports2025

Renal Dysfunction Across the Spectrum of Cardiogenic Shock: Mechanisms, Clinical Implications, and Therapeutic Strategies.

Diana De Oliveira-Gomes, Christian Guilliod, Ilan Vavilin, Ankeet Bhatt, Brendon Neuen, Jamie L W Kennedy, Manreet Kanwar, Megan Terek, Shashank S Sinha, Van-Khue Ton and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current heart failure reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Diana De Oliveira-GomesDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Christian GuilliodDepartment of Internal Medicine, University of Miami/Jackson Health System, Miami, FL, USA.
Ilan VavilinFalls Church, Inova Schar Heart and Vascular Institute, Inova Fairfax Medical Campus, 3300 Gallows Road,, Falls Church, VA, 22042, USA.
Ankeet BhattDivision of Research, Kaiser Permanente Northern California,, San Francisco, CA, USA.
Brendon NeuenThe George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
Jamie L W KennedyFalls Church, Inova Schar Heart and Vascular Institute, Inova Fairfax Medical Campus, 3300 Gallows Road,, Falls Church, VA, 22042, USA.
Manreet KanwarDivision of Cardiology, University of Chicago, Chicago, IL, USA.
Megan TerekFalls Church, Inova Schar Heart and Vascular Institute, Inova Fairfax Medical Campus, 3300 Gallows Road,, Falls Church, VA, 22042, USA.
Shashank S SinhaFalls Church, Inova Schar Heart and Vascular Institute, Inova Fairfax Medical Campus, 3300 Gallows Road,, Falls Church, VA, 22042, USA.
Van-Khue TonCardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Mitchell PsotkaFalls Church, Inova Schar Heart and Vascular Institute, Inova Fairfax Medical Campus, 3300 Gallows Road,, Falls Church, VA, 22042, USA.
Vanessa BlumerFalls Church, Inova Schar Heart and Vascular Institute, Inova Fairfax Medical Campus, 3300 Gallows Road,, Falls Church, VA, 22042, USA. Vanessa.blumer@inova.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review aims to elucidate the complex interplay between cardiogenic shock (CS) and renal function, detailing the mechanisms of kidney injury, identifying risk factors, and providing a framework for the diagnosis and management of acute kidney injury (AKI) in CS. We evaluate evidence supporting medical interventions, including vasopressors, inotropes, and mechanical circulatory support (MCS), in relation to renal outcomes. RECENT

findingsAKI affects up to 80% of patients with CS and is associated with higher mortality, especially when Renal Replacement Therapy (RRT) is required. Mechanisms include impaired perfusion, venous congestion, and systemic inflammation. Invasive hemodynamic assessment improves diagnostic accuracy. Continuous RRT is preferred in unstable patients, although early initiation has not been shown to provide a survival benefit. Emerging tools such as novel biomarkers and machine learning may aid in early detection and risk stratification. AKI in CS is common and multifactorial, with significant prognostic impact. Early recognition, hemodynamic optimization, and a multidisciplinary strategy remain essential. Future work should focus on individualized management approaches to improve outcomes.

Indexed as

Acute Kidney InjuryShock, CardiogenicHumansPrognosisRenal Replacement TherapyRisk FactorsAcute kidney injuryCardiogenic shockCardiorenal syndromeRenal replacement therapy

Identifiers

PMID40560292

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.