Evidence map›Paper›PMID 40560379›Full record

ArticlePathologie (Heidelberg, Germany)2025

[N-cadherin as a novel diagnostic marker : Differentiation of primary liver tumours from metastases of an extrahepatic primary tumour].

Tiemo S Gerber, Dirk A Ridder, Wilfried Roth, Beate K Straub

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In one paragraph

Article in Pathologie (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tiemo S GerberInstitut für Pathologie, Klinikum Worms GmbH, Gabriel-von-Seidl-Straße 81, 67550, Worms, Deutschland. TiemoSven.Gerber@klinikum-worms.de.ORCID http://orcid.org/0000-0001-9910-2186
Dirk A RidderInstitut für Pathologie, Ludwigshafen, Deutschland.
Wilfried RothInstitut für Pathologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Deutschland.
Beate K StraubInstitut für Pathologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The differential diagnosis of intrahepatic cholangiocarcinomas (iCCA), hepatocellular carcinomas (HCC) and liver metastases of extrahepatic primary tumours is crucial but may be challenging. N‑cadherin, a transmembrane glycoprotein of adherens junctions, is typical for neural and mesenchymal cells, whereas most epithelia and carcinomas derived therefrom are negative for N‑cadherin. However, hepatocytes and cholangiocytes, along with HCC and iCCA, are exceptions as they exhibit expression of N‑cadherin, making this a valuable immunohistochemical marker. We previously showed in a study on 3359 tumours that N‑cadherin positivity reliably differentiates primary liver carcinomas from liver metastases of extrahepatic carcinomas. N‑cadherin therefore complements the immunohistochemical panel in the differential diagnosis of carcinoma of unknown primary (CUP).

Indexed as

Bile Duct NeoplasmsCadherinsCarcinoma, HepatocellularCholangiocarcinomaLiver NeoplasmsNeoplasms, Unknown PrimaryAntigens, CDBile Ducts, IntrahepaticBiomarkers, TumorDiagnosis, DifferentialHumansAntigens, CDBiomarkers, TumorCadherinsAdherens junctionsCholangiocarcinomaDifferential diagnosisHepatocellular carcinomaUnknown primary neoplasms

Identifiers

PMID40560379

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.