Evidence map›Paper›PMID 40560401›Full record

ArticleMolecular biology of the cell2025

Phosphorylation of Golgin Imh1 by AMPK/Snf1 compromises Golgi compartmentalization by releasing Arl1-Imh1 axis.

Pei-Juan Cai, Chia-Jung Yu, Fang-Jen S Lee

Abstract read
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Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pei-Juan CaiInstitute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 100225, Taiwan.
Chia-Jung YuDepartment of Cell and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.
Fang-Jen S LeeInstitute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 100225, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Golgins, coiled-coil proteins, are crucial for Golgi architecture and intracellular transport. Mammals have four GRIP-domain-containing Golgins, while budding yeast has a single conserved Golgin, Imh1. Imh1 is recruited to the Golgi membrane by the active small GTPase Arl1 via its GRIP domain. Despite extensive phosphorylation of Imh1 under various stress conditions observed in previous screenings, the biological significance and regulatory mechanisms of Imh1 phosphorylation remain unclear. This study reveals that Snf1, a yeast AMPK homologue, regulates the dissociation of the Arl1-Imh1 axis from the Golgi during glucose deprivation by phosphorylating Imh1 at Ser606, Ser802, and Ser804. The phosphomimetic mutant Imh1

Indexed as

ADP-Ribosylation FactorsAMP-Activated Protein KinasesGolgi ApparatusProtein Serine-Threonine KinasesSaccharomyces cerevisiae ProteinsGlucoseGolgi Matrix ProteinsMonomeric GTP-Binding ProteinsPhosphorylationProtein TransportSaccharomyces cerevisiaeVesicular Transport ProteinsADP-Ribosylation FactorsAMP-Activated Protein KinasesARL1 protein, S cerevisiaeGlucoseGolgi Matrix ProteinsMonomeric GTP-Binding ProteinsProtein Serine-Threonine KinasesSaccharomyces cerevisiae ProteinsSNF1-related protein kinasesVesicular Transport Proteins

Identifiers

PMID40560401
PMCPMC12367314

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.