Evidence map›Paper›PMID 40560498›Full record

ArticleAnnals of surgical oncology2026

Consensus Guideline for the Management of Patients with Appendiceal Tumors, Part 1: Appendiceal Tumors Without Peritoneal Involvement.

Elizabeth L Godfrey, Forest Mahoney, Varun V Bansal, David G Su, David N Hanna, Felipe Lopez-Ramirez, Ekaterina Baron, Kiran K Turaga, Al B Benson, James Cusack and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Elizabeth L GodfreyDepartment of Surgery, Yale School of Medicine, New Haven, CT, USA.
Forest MahoneyYale School of Medicine, New Haven, CT, USA.
Varun V BansalDepartment of Surgery, Yale School of Medicine, New Haven, CT, USA.
David G SuDepartment of Surgery, Yale School of Medicine, New Haven, CT, USA.
David N HannaSection of Surgical Sciences, Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Felipe Lopez-RamirezDepartment of Surgical Oncology, Mercy Medical Center, The Institute for Cancer Care, Baltimore, MD, USA.
Ekaterina BaronDivision of Surgical Oncology, Marshfield Medical Center, Marshfield, WI, USA.
Kiran K TuragaDepartment of Surgery, Yale School of Medicine, New Haven, CT, USA. kiran.turaga@yale.edu.
Al B BensonDivision of Hematology and Oncology, Department of Medicine, Northwestern University, Chicago, IL, USA.
James CusackDivision of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Joshua H WinerDivision of Surgical Oncology, Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA.
Craig G GundersonDepartment of Surgery, Yale School of Medicine, New Haven, CT, USA.
Joseph MisdrajiDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Rupen ShahDivision of Surgical Oncology, Henry Ford Cancer Institute/Henry Ford Health, Detroit, MI, USA.
Deepa R MaggeSection of Surgical Sciences, Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Ian SolskyDivision of Surgical Oncology, Department of Surgery, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Cathy EngDivision of Hematology and Oncology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Oliver S EngDivision of Surgical Oncology, Department of Surgery, University of California Irvine, Orange, CA, USA.
Ardaman ShergillSection of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
John Paul ShenDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michael B FooteDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Peritoneal Surface Malignancies (PSM) Consortium Group

Funding

Surgical Oncology Training GrantT32CA106183 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI James Richard Goldenring · 2004 to 2026
$6.0M
Yale Cancer Center Advanced Training Program for Physician-Scientists (YCC-ATPP)T32CA233414 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 2019 to 2026
$3.2M
Cancer Prevention and Research Institute of Texas CPRIT Scholar in Cancer Research [RR180035]Conquer Cancer Foundation Career Development AwardNCI NIH HHS T32 CA106183NCI NIH HHS T32 CA233414
6 · The paper itself

Abstract

backgroundAppendiceal tumors comprise a heterogeneous group of tumors that may be localized or disseminate throughout the peritoneum. Limited high quality clinical data exist and many practices have been extrapolated from colorectal cancer without validation in appendiceal cohorts. There are many controversies regarding the treatment of appendiceal tumors, and practices vary widely between centers and care settings. A national consensus update of best management practices for appendiceal malignancies was performed to better standardize care.

methodsThe 2018 Chicago Consensus guideline was updated through a modified Delphi consensus, performed over two rounds using nationally circulated surveys. Supporting evidence was evaluated using rapid systematic reviews. Key systemic therapy concepts were summarized by content experts.

resultsMost supporting literature consists of observational studies, but high-quality studies increasingly are becoming available to drive management. Two consensus-based pathways were generated for localized appendiceal tumors, one for epithelial mucinous neoplasms and another for appendiceal adenocarcinoma. Of 138 participants responding in the first round, 133 (96%) engaged in the second round. Greater than 90% consensus was achieved for all pathway blocks. Key points include minimizing intervention invasiveness where permitted by pathologic classification and margin status, and determining which margin and pathologic findings are indications for consideration of cytoreduction with or without intraperitoneal chemotherapy. Surveillance and systemic therapy recommendations are also presented.

conclusionWith growing but still primarily observational evidence currently dictating care, these consensus recommendations provide expert guidance in the treatment of appendiceal tumors without peritoneal involvement.

Indexed as

Appendiceal NeoplasmsPeritoneal NeoplasmsPractice Guidelines as TopicConsensusCytoreduction Surgical ProceduresDelphi TechniqueHumansPrognosisAppendiceal malignanciesCytoreductive surgical proceduresGuidelinesPeritoneal neoplasmsPeritoneal surface malignancies

Identifiers

PMID40560498

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.