Evidence map›Paper›PMID 40560794›Full record

ArticleJournal of extracellular vesicles2025

Programmed Cell Death Protein 10 (PDCD10) Regulates Vesicle Trafficking and Contributes to the Progression of Clear Cell Renal Cell Carcinoma.

Rui Wang, Tianyu Lin, Yi Liu, Hao Wang, Xinyu Liu, Yihan Dong, Jiaxin Li, Huamao Jiang, Ruibing Chen, Yong Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rui WangDepartment of Clinical Microbiology, School of Medical Technology, Tianjin Medical University, Tianjin, China.
Tianyu LinDepartment of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Yi LiuSchool of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, China.
Hao WangDepartment of Clinical Laboratory, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.
Xinyu LiuDepartment of Clinical Microbiology, School of Medical Technology, Tianjin Medical University, Tianjin, China.
Yihan DongDepartment of Clinical Microbiology, School of Medical Technology, Tianjin Medical University, Tianjin, China.
Jiaxin LiDepartment of Clinical Microbiology, School of Medical Technology, Tianjin Medical University, Tianjin, China.
Huamao JiangDepartment of Urology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Ruibing ChenSchool of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, China.
Yong WangDepartment of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Dan YueDepartment of Clinical Microbiology, School of Medical Technology, Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0000-0002-4220-4920

Funding

National College Students Innovation and Entrepreneurship Training Program 202510062003National College Students Innovation and Entrepreneurship Training Program 202510062048National Natural Science Foundation of China 22474087National Natural Science Foundation of China 82203360Natural Science Foundation of Tianjin Municipality 22JCYBJC00550Tianjin Health Science and Technology Project TJWJ2024XK007Tianjin Medical University Education Teaching Research Project PX-18232540
6 · The paper itself

Abstract

Vesicle trafficking is an essential cellular process that plays an important role in tumour progression. Here, we performed a comprehensive transcriptomic and proteomic analysis on 50 clear cell renal cell carcinoma (ccRCC) tumour samples, and the data systematically depicted the alterations in the molecular landscape. Intriguingly, our investigation uncovered profound dysregulation of the vesicle trafficking process. Particularly, PDCD10 was overexpressed in ccRCC, and functional assays showed that PDCD10 promoted cell proliferation, migration and invasion in vitro and enhanced tumour growth in vivo. Additionally, we identified PDCD10 as a critical regulator of endocytosis and exosome secretion. Proteomic analysis of extracellular vesicles (EVs) suggested that PDCD10 overexpression altered the cargo content in EVs and elevated the abundances of cell adhesion and extracellular matrix molecules. Furthermore, Erlotinib treatment impaired PDCD10-induced endocytosis and suppressed cell proliferation and invasion. Collectively, our findings underscore the significance of PDCD10 as a regulator of vesicle trafficking in ccRCC and a potential target for developing novel anticancer therapeutics.

Indexed as

Apoptosis Regulatory ProteinsCarcinoma, Renal CellExtracellular VesiclesKidney NeoplasmsMembrane ProteinsAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionEndocytosisExosomesGene Expression Regulation, NeoplasticHumansMiceProteomicsApoptosis Regulatory ProteinsMembrane ProteinsPDCD10 protein, humanProto-Oncogene Proteinsextracellular vesiclesPDCD10proteomicsrenal cell carcinomavesicle trafficking

Identifiers

PMID40560794
PMCPMC12190551

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.