Evidence map›Paper›PMID 40562311›Full record

ArticleMolecular metabolism2025

Creatine kinase B mediates UCP1-independent beige fat thermogenesis via the futile creatine cycle in mice.

Jakub Bunk, Mina Ersin, Mohammed F Hussain, Bozena Samborska, Maria Guerra-Martinez, Drishti Soni, Lawrence Kazak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jakub BunkRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.
Mina ErsinRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.
Mohammed F HussainRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.
Bozena SamborskaRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada.
Maria Guerra-MartinezRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.
Drishti SoniRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.
Lawrence KazakRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada. Electronic address: lawrence.kazak@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCreatine kinase B (CKB) is the main isoenzyme driving creatine kinase (CK) activity in classical brown adipocytes. However, the specific CK isoenzyme active in beige adipocytes remains unknown. This study aimed to identify the predominant CK isoenzyme expressed and functionally active in beige adipocytes.

methodsCK activity was tracked using D3-creatine tracing in inguinal adipocytes from mice with adipocyte-specific Ckb deletion and their littermate controls, across in vivo and in vitro settings.

resultsCKB was essential for CK activity in protein lysates and intact white and beige adipocytes isolated from inguinal fat and drives thermogenesis through the Futile Creatine Cycle.

conclusionsSimilar to classical brown adipocytes, CKB is the key functional CK isoenzyme in white and beige adipocytes from the inguinal fat depot.

Indexed as

Adipocytes, BeigeAdipose Tissue, BeigeCreatineCreatine Kinase, BB FormThermogenesisUncoupling Protein 1AnimalsMaleMiceMice, Inbred C57BLMice, KnockoutCreatineCreatine Kinase, BB FormUcp1 protein, mouseUncoupling Protein 1Beige adipocytesCreatine Kinase BFutile Creatine CycleInguinal white adipose tissueInterscapular brown adipose tissueIsotope tracingTissue-nonspecific alkaline phosphataseUCP1-indpendent thermogenesis

Identifiers

PMID40562311
PMCPMC12271865

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.