Evidence map›Paper›PMID 40562749›Full record

ArticleNature communications2025

ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution.

Flavia W de Faria, Nicole C Riedel, Daniel Münter, Marta Interlandi, Carolin Göbel, Lea Altendorf, Mathis Richter, Viktoria Melcher, Christian Thomas, Rajanya Roy and 29 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Modeling pediatric brain tumors with human stem cells.Frontiers in cellular neuroscience · 2026
    Review
  4. Organoids glimpse: the nexus for diverse tumor heterogeneity.Frontiers in cell and developmental biology · 2026
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Flavia W de Faria *Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Nicole C Riedel *Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Daniel MünterDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-8823-0238
Marta InterlandiDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Carolin GöbelDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7345-2089
Lea AltendorfDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Mathis RichterInstitute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-3110-6137
Viktoria MelcherDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Christian ThomasInstitute of Neuropathology, University Hospital Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-6642-7774
Rajanya RoyDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Melanie SchoofDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-1373-8130
Ivan BedzhovEmbryonic Self-Organization Research Group, Max Planck Institute for Molecular Biomedicine, Münster, Germany.ORCID http://orcid.org/0000-0002-2122-6485
Natalia MorenoDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Monika GrafDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Marc HotfilderDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Dörthe HoldhofDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0003-4664-3848
Wolfgang HartmannDivision of Translational Pathology, Gerhard-Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-7609-5021
Ann-Katrin BrunsDepartment of Neurosurgery, University Hospital Münster, Münster, Germany.
Angela BrentrupDepartment of Neurosurgery, University Hospital Münster, Münster, Germany.
Friederike Liesche-StarneckerDepartment of Neuropathology, Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany.
Bruno MaerklDepartment of Neuropathology, Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany.
Sarah SandmannInstitute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany.
Julian VargheseInstitute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-7206-3719
Martin DugasInstitute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-9740-0788
Pedro H PintoDepartment of Pathology, Children's Hospital of Brasilia Jose de Alencar, Brasilia, Brazil.
Sebastian T BalbachDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-0212-5758
I-Na LuDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-3845-7386
Claudia RossigDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Oliver SoehnleinInstitute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-7854-0694
Aysegül CanakDepartment of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany.
Martin EbingerDepartment of Neurosurgery, section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-4229-8058
Martin SchuhmannDepartment of Neurosurgery, section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-9843-7486
Jens SchittenhelmDepartment of Neuropathology, University Medical Hospital, Eberhard Karls University Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-9168-6209
Michael F FrühwaldSwabian Children's Cancer Center, Pediatric and Adolescent Medicine, University Center Augsburg, Augsburg, Germany.ORCID http://orcid.org/0000-0002-8237-1854
Ulrich SchüllerDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-8731-1121
Thomas K AlbertDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-2488-0706
Carolin WalterDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Jan M BruderDepartment for Cell and Developmental Biology, Max Planck Institute for molecular Biomedicine, Münster, Germany.
Kornelius KerlDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany. kornelius.kerl@ukmuenster.de.ORCID http://orcid.org/0000-0002-5676-8102

Funding

Deutsche Kinderkrebsstiftung (German Childhood Cancer Foundation) 2023.06Wilhelm Sander-Stiftung (Wilhelm Sander Foundation) 2023.023.1
6 · The paper itself

Abstract

Embryonal tumor with multilayered rosettes (ETMR) is a lethal embryonal brain tumor entity. To investigate the intratumoral heterogeneity and cellular communication in the tumor microenvironment (TME), we analyze in this work single-cell RNA sequencing of about 250,000 cells of primary human and murine ETMR, in vitro cultures, and a 3D forebrain organoid model of ETMR, supporting the main findings with immunohistochemistry and spatial transcriptomics of human tumors. We characterize three distinct malignant ETMR subpopulations - RG-like, NProg-like and NB-like - positioned within a putative neurodevelopmental hierarchy. We reveal PDGFRβ

Indexed as

Brain NeoplasmsDrug Resistance, NeoplasmNeoplastic Stem CellsPericytesAnimalsCell CommunicationCell DifferentiationCell Line, TumorHumansMiceOrganoidsPlatelet-Derived Growth FactorReceptor, Platelet-Derived Growth Factor betaSignal TransductionSingle-Cell AnalysisTumor MicroenvironmentPlatelet-Derived Growth FactorReceptor, Platelet-Derived Growth Factor beta

Identifiers

PMID40562749
PMCPMC12198369

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.