ArticleNature chemical biology2026
A pseudoenzyme enables indole biosynthesis in eudicot plants.
Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Tuning reductase activity in monoterpene indole alkaloid biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Leaf Developmental Stages Strongly Modulate Indole Emissions in Response to Simulated Insect Herbivory.Plants (Basel, Switzerland) · 2025Article
- Independent evolution of plant natural products: Formation of benzoxazinoids in Consolida orientalis (Ranunculaceae).The Journal of biological chemistry · 2025Article
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Authors and funding
7 authors.
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Abstract
Indole is an important biomolecule in plants, essential for amino acid biosynthesis, defense, pollinator attraction and plant-plant communication. Its biosynthesis is reported to be catalyzed by standalone indole-3-glycerol phosphate lyases, which are, however, absent in core eudicots. Here we show that, in core eudicots, indole production for defense and signaling occurs through an alternative pathway. The tryptophan synthase α subunit (TSA), which is typically complexed with the β subunit (TSB) to synthesize tryptophan through indole as an intermediate, can be hijacked by a noncatalytic paralog of TSB (TSB-like) to produce free indole. TSB-like is a pseudoenzyme that evolved from TSB by mutagenesis of two key essential residues, retaining the ability to allosterically activate TSA to allow formation and release of indole. The widespread occurrence and expression pattern of TSB-like genes in plants suggest that this is a general mechanism for the formation of free indole in plant defense and communication.
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