Evidence map›Paper›PMID 40562934›Full record

ArticleNature2025

Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in mice.

Homa Majd, Ryan M Samuel, Andrius Cesiulis, Jonathan T Ramirez, Ali Kalantari, Kevin Barber, Sina Farahvashi, Zaniar Ghazizadeh, Alireza Majd, Angeline K Chemel and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Combinatorial multiomic analysis from a pedigree of Sox10bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Homa MajdDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Ryan M SamuelDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Andrius CesiulisDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Jonathan T RamirezDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3814-861X
Ali KalantariEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Kevin BarberEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Sina FarahvashiDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Zaniar GhazizadehDivision of Cardiovascular Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Alireza MajdDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0036-2725
Angeline K ChemelDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Mikayla N RichterDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-7632-738X
Subhamoy DasDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, USA.
Jacqueline L BendrickStanford Neurosciences Interdepartmental Program, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2694-9914
Matthew G KeefeDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2477-2975
Jeffrey WangDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Rahul K ShivDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Samyukta BhatEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Matvei KhoroshkinDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Johnny YuDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Tomasz J NowakowskiDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
Kwun Wah WenDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Hani GoodarziDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9648-8949
Nikhil ThaparStem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK.
Julia A KaltschmidtDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2893-1793
Conor J McCannStem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-9324-5984
Faranak FattahiDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA. Faranak.Fattahi@ucsf.edu.ORCID 0000-0002-9473-8596

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
DIABETES, ENDOCRINOLOGY &METABOLISM TRAINING PROGRAMT32DK007418 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 1986 to 2026
$14.3M
PREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7M
An antisense RNA-mediated regulatory program that drives cancer metastasisR01CA240984 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOODARZI, HANI · 2019 to 2023
$2.5M
Modeling Neurodegenerative Disease Manifestations in Human Enteric NeuronsDP2NS116769 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FATTAHI, FARANAK · 2019 to 2019
$2.4M
Human pluripotent stem cells for the study of gastrointestinal dysmotilityR01DK121169 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FATTAHI, FARANAK · 2020 to 2024
$1.8M
NCI NIH HHS R01 CA240984NICHD NIH HHS T32 HD007470NIDDK NIH HHS R01 DK121169NIDDK NIH HHS T32 DK007418NIMH NIH HHS T32 MH020016NINDS NIH HHS DP2 NS116769
6 · The paper itself

Abstract

Gastrointestinal (GI) motility disorders represent a major medical challenge, with few effective therapies available. These disorders often result from dysfunction of inhibitory nitric oxide (NO)-producing motor neurons in the enteric nervous system, which are essential for regulating gut motility. Loss or dysfunction of NO neurons is linked to severe conditions, including achalasia, gastroparesis, intestinal pseudo-obstruction and chronic constipation

Indexed as

Gastrointestinal MotilityNitrergic NeuronsPluripotent Stem CellsAnimalsCell DifferentiationColonEnteric Nervous SystemFemaleHumansMaleMiceNitric OxideNitric Oxide

Identifiers

PMID40562934
PMCPMC12408359

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.