ArticleRenal failure2025
Intraoperative 20% albumin infusion and acute kidney injury in on-pump cardiac surgery: a focus on preoperative albumin levels.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Albumin Concentration and Timing on Acute Kidney Injury After Adult Cardiac Surgery: A Systematic Review and Meta-analysis.Annals of cardiac anaesthesia · 2026Pooled it
- Albumin in Cardiac Surgery-Associated Acute Kidney Injury: Therapeutic Target or Epiphenomenon?Annals of cardiac anaesthesia · 2026Article
- Evaluating the Role of Advanced Age and Risk Factors in Postoperative Outcomes Following Major Lung Cancer Resection.Thoracic cancer · 2026Article
- Targeted Albumin Administration in Cardiac Surgery: Refining Perioperative Fluid Strategy.Reviews in cardiovascular medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlbumin is widely used for volume replacement therapy during cardiopulmonary bypass (CPB) including priming fluid, despite significant controversy over its benefits. This study aimed to examine how 20% exogenous albumin affects kidney function in patients with varying preoperative albumin levels.
methodsWe conducted this single-center, retrospective study in 28,298 adult patients undergoing on-pump cardiac surgery between 2018 and 2023. Patients were stratified according to preoperative albumin values (g/L): ≤35 (
resultsA total of 2,541 pairs were created after PSM: ≤ 35 g/L (307 pairs), 35.1-37.5 g/L (518 pairs), 37.6-40 g/L (743 pairs), and > 40 g/L (973 pairs). Patients with intraoperative 20% albumin infusion had a statistically higher risk of CSA-AKI in the group with preoperative albumin above 40 g/L (OR, 1.29; 95% CI, 1.07-1.57;
conclusionsThis analysis highlights that 20% albumin infusion during on-pump cardiac surgery may increase the risk of all stages CSA-AKI in patients with preoperative albumin above 40 g/L.
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