ArticleRenal failure2025
Associations between per- and polyfluoroalkyl substances exposure and renal function as well as poor prognosis in chronic kidney disease patients.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Environmental Pollution and Its Impact on Kidney Diseases: A Comprehensive Review of Current Evidence.Life (Basel, Switzerland) · 2026Review
- Per- and Polyfluoroalkyl Substances (PFAS): History, Current Concerns, and Future Outlook.Molecules (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objectives of this study were to investigate the associations of single and mixed exposure to the environmental pollutants per- and polyfluoroalkyl substances (PFAS) with renal function and mortality in non-dialysis chronic kidney disease (CKD) patients.
methodsNon-dialysis CKD1-4 stage patients in the 2003-2018 US National Health and Nutrition Examination Survey (NHANES) who were ≥20 years old were included. Five PFAS were measured and all patients were followed up till 31 December 2019. Multivariate linear, logistic, and Cox regressions were used to evaluate the associations between PFAS exposure and renal function, mortality. Stratified subgroups were analyzed based on baseline characteristics. Bayesian kernel machine regression (BKMR) was used in sensitivity analysis.
resultsAmong 1503 CKD patients included, baseline renal function declined in 701 patients (44.4%) and 462 patients (24.9%) died during the follow-up. Single exposure to perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS) was positively associated with renal function decline (
conclusionsPFAS single and mixed exposure were closely related to renal function and renal progression in adult CKD patients. There was no statistically significant association between PFAS exposure and mortality.
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Registered trials
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