ReviewAntioxidants (Basel, Switzerland)2025
The Dual Role of Dietary Phytochemicals in Oxidative Stress: Implications for Oncogenesis, Cancer Chemoprevention, and ncRNA Regulation.
Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Trial
- Anticancer Activity of Miswak Root Extract in Breast Cancer Cell Line: HRLC-MS/MS Profiling, In Vitro Evaluation, and In Silico Analysis.International journal of molecular sciences · 2026Article
- Dietary Phytochemicals in Cancer Therapy-From Mechanistic Insights to Combination Strategies.Nutrients · 2026Article
- Article
- Article
- Impact of body mass index on dietary habits and health behaviors in breast cancer patients.Frontiers in oncology · 2026Article
- ExploringAnimals : an open access journal from MDPI · 2025Article
- Prophylactic Olive Leaf Tea as a Nutraceutical Strategy: Tumor Suppression and Systemic Protection.Current issues in molecular biology · 2025Article
- Oral submucosal fibrosis: a comprehensive review on pathogenesis, diagnosis, therapeutics and computational advances.Frontiers in cell and developmental biology · 2025Review
- Seasonal Metabolic Adaptations and Antioxidant Defense Mechanisms in the Resilience ofScientifica · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress (OS), resulting from an imbalance between reactive oxygen species (ROS) and the antioxidant defense system, plays a critical role in the initiation and progression of cancer. Recent research has highlighted the regulatory influence of non-coding RNAs (ncRNAs) on cancer initiation and development through the regulation of redox homeostasis and key signaling pathways, which makes them potential targets for anticancer therapy. The ncRNA-oxidative stress axis contributes to malignancy through DNA damage, altered signaling, and dysregulated molecular networks. Plant-derived dietary components and phytochemicals have garnered significant attention for their ability to restore ROS balance and modulate the ncRNA/OS axis, thereby inhibiting carcinogenesis and enhancing the efficacy of chemotherapy. To study the interplay between OS, ncRNAs, and the anticancer potential of plant-derived compounds, in this review, we conducted an extensive search of electronic databases to identify and analyze studies that explore the interwork between OS, ncRNAs, and the chemotherapeutic role of phytochemicals. We discuss the dual role of phytochemicals in both cancer induction and suppression, emphasizing their capacity to generate ROS and regulate ncRNA expression. Furthermore, the review underscores the importance of nutritional interventions and antioxidant regulation in cancer chemoprevention and therapy, including the interconnected roles of oxidative stress, ncRNAs, and phytochemicals in cancer development and treatment, with a focus on dietary modulation as a strategic approach in oncology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.