Evidence map›Paper›PMID 40563289›Full record

ReviewAntioxidants (Basel, Switzerland)2025

Emerging Trends in Green Extraction Techniques, Chemical Modifications, and Drug Delivery Systems for Resveratrol.

Sonia Trombino, Roberta Cassano, Maria Luisa Di Gioia, Francesca Aiello

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Resveratrol-EnrichedNutrients · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Ultrasound-Assisted Extraction of Bioactives fromFoods (Basel, Switzerland) · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sonia TrombinoDepartment of Pharmacy, Health and Nutritional Science, University of Calabria, Arcavacata, 87036 Rende, Italy.ORCID 0000-0001-9939-4457
Roberta CassanoDepartment of Pharmacy, Health and Nutritional Science, University of Calabria, Arcavacata, 87036 Rende, Italy.ORCID 0000-0001-6980-6799
Maria Luisa Di GioiaDepartment of Pharmacy, Health and Nutritional Science, University of Calabria, Arcavacata, 87036 Rende, Italy.ORCID 0000-0001-5469-5459
Francesca AielloDepartment of Pharmacy, Health and Nutritional Science, University of Calabria, Arcavacata, 87036 Rende, Italy.ORCID 0000-0001-6846-5582

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resveratrol is a naturally occurring phytoalexin found in red grapes, cocoa berries, and red grape wine. This compound exhibits potent antioxidant, anti-inflammatory, and anticancer properties. However, its clinical application is significantly hindered by poor aqueous solubility and rapid degradation at physiological pH, resulting in extremely low systemic bioavailability. This review explores three key aspects: green extraction methods for the efficient and sustainable isolation of resveratrol; structure-activity relationship studies of resveratrol derivatives to identify compounds with improved bioavailability and therapeutic efficacy; and advanced drug delivery systems to enhance resveratrol solubility, stability, and achieve targeted tissue delivery. All of these solutions collectively aim to increase resveratrol bioavailability, enabling the development of effective pharmaceutical formulations and maximizing the clinical potential of this promising compound. The aim of this review is to summarize the key studies published in the last five years, highlighting innovative advancements in sustainable extraction, structural modifications, and delivery strategies for resveratrol.

Indexed as

drug delivery systemsgreen extractiongreen solventsresveratrolresveratrol derivativesstructure-activity relationships

Identifiers

PMID40563289
PMCPMC12189258

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.