ReviewAntioxidants (Basel, Switzerland)2025
Role of Redox-Induced Protein Modifications in Spermatozoa in Health and Disease.
Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Proteomic Landscape of Spermatozoa Under Inflammatory and Oxidative Injury: Molecular Mechanisms and Clinical Translation.Antioxidants (Basel, Switzerland) · 2026Review
- Proteomic insights into azoospermia: protein differences in testicular tissue between non-obstructive and obstructive azoospermia patients.Asian journal of andrology · 2026Article
- Spinal Cord Injury-Related Male Infertility: Oxidative Stress, Inflammation, and Sperm DNA Damage.Journal of clinical medicine · 2026Review
- The Positive Roles for Reactive Oxygen Species in Human Reproduction; Implications for the Therapeutic Application of Antioxidants.Antioxidants (Basel, Switzerland) · 2026Review
- Levels of Protein CoAlation Regulate Redox Signaling Events of Human Sperm Capacitation.Antioxidants (Basel, Switzerland) · 2026Article
- Fecal Microbial Community Characteristics of Oula and Hu Sheep and Their Correlation with Semen Quality.Animals : an open access journal from MDPI · 2026Article
- Prostatitis-Related Male Infertility: From Inflammation and Dysbiosis to Sperm DNA Damage.Diagnostics (Basel, Switzerland) · 2026Review
- Oxidative Stress and Inflammatory Biomarkers in Male Infertility: A Narrative Review of Diagnostic Value and Clinical Integration.Diagnostics (Basel, Switzerland) · 2026Review
- Redox-Genomic Crosstalk: Linking Oxidative Stress, Sperm DNA Fragmentation, and Epigenetics in Personalized Management of Male Infertility.Journal of personalized medicine · 2026Review
- Review
- Carissa spinarum L. aqueous root extracts ameliorate oxidative stress-induced infertility in adult male Wistar rats.PloS one · 2026Article
- Research progress on the multidimensional mechanisms underlying impaired spermatogenesis induced by pathological microenvironment remodeling in chronic prostatitis.Frontiers in immunology · 2026Review
- Recent advances in the investigation of the regulatory network underlying reactive nitrogen species-mediated tumorigenesis: molecular mechanisms and targeted therapeutic strategies.Redox report : communications in free radical research · 2025Review
- Impact of selenium and selenoproteins on idiopathic male infertility: a comprehensive review.Frontiers in nutrition · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Male infertility contributes to approximately half of all infertility cases, with most cases associated with oxidative stress. Spermatozoa depend on finely tuned redox signaling for critical processes such as capacitation, motility, and fertilization competence; however, their unique structural and metabolic features render them particularly vulnerable to oxidative damage. Reversible oxidative modifications regulate enzymatic activity, signaling cascades, and structural stability, supporting normal sperm function, whereas irreversible oxidative damage impairs motility, acrosome reaction, and DNA integrity, contributing to male infertility. The intricate balance between physiological redox signaling and pathological oxidative stress demonstrates the potential of redox modifications as biomarkers for infertility diagnosis and as targets for antioxidant-based therapeutic interventions. This review explores the role of redox-induced protein modifications in sperm function, focusing on thiol oxidation, S-nitrosylation, sulfhydration, glutathionylation, CoAlation, and protein carbonylation. By uncovering the mechanisms of these redox modifications, we provide a framework for their modulation in the development of targeted redox interventions to improve male fertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.