Evidence map›Paper›PMID 40563414›Full record

ArticleBiomolecules2025

Molecular Dynamics Simulations of Plasma-Antifolate Drug Synergy in Cancer Therapy.

Yanxiong Niu, Tong Zhao, Xiaolong Wang, Ying Sun, Yuantao Zhang

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yanxiong NiuSchool of Electrical Engineering, Shandong University, Ji'nan 250061, China.
Tong ZhaoSchool of Electrical Engineering, Shandong University, Ji'nan 250061, China.ORCID 0000-0003-0523-4466
Xiaolong WangSchool of Electrical Engineering, Shandong University, Ji'nan 250061, China.
Ying SunSchool of Electrical Engineering, Shandong University, Ji'nan 250061, China.ORCID 0000-0001-7316-2236
Yuantao ZhangSchool of Electrical Engineering, Shandong University, Ji'nan 250061, China.ORCID 0000-0002-1051-5062

Funding

National Natural Science Foundation of China 52077128National Natural Science Foundation of China 52177224
6 · The paper itself

Abstract

Reactive oxygen species (ROS) generated by cold atmospheric plasma (CAP) cause irreversible damage to cancer cell DNA, RNA, mitochondria, and antioxidant defense systems, leading to apoptosis. Plasma-induced disruption of the antioxidant defense system of cancer cells by cystine uptake via xC

Indexed as

Folic Acid AntagonistsMolecular Dynamics SimulationNeoplasmsPemetrexedPlasma GasesDrug SynergismHumansOxidation-ReductionTetrahydrofolates5-methyltetrahydrofolateFolic Acid AntagonistsPemetrexedPlasma GasesTetrahydrofolates5-MTHFhSLC19A1molecular dynamics simulationpemetrexedplasma-assisted cancer therapy

Identifiers

PMID40563414
PMCPMC12191190

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.