Evidence mapPaperPMID 40563540Full record

ArticleBiomolecules2025

Adaptation to Arginine Deprivation Leads to a More Aggressive, Therapy-Resistant Phenotype in HNSCC Cells.

Oleg Chen, Olena Vovk, Nikita Polishchuk, Oksana Mayevska, Galyna Shuvayeva, Melike Demir, Vasyl Lukiyanchuk, Leoni A Kunz-Schughart, Anna Dubrovska, Oleh Stasyk

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Oleg ChenDepartment of Cell Signaling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str. 14/16, 79005 Lviv, Ukraine.ORCID 0000-0003-0875-642X
Olena VovkDepartment of Cell Signaling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str. 14/16, 79005 Lviv, Ukraine.ORCID 0000-0001-6703-457X
Nikita PolishchukDepartment of Cell Signaling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str. 14/16, 79005 Lviv, Ukraine.ORCID 0009-0007-2915-4117
Oksana MayevskaDepartment of Cell Signaling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str. 14/16, 79005 Lviv, Ukraine.ORCID 0000-0003-2071-322X
Galyna ShuvayevaDepartment of Cell Signaling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str. 14/16, 79005 Lviv, Ukraine.ORCID 0000-0001-7803-3900
Melike DemirOncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf, 01309 Dresden, Germany.
Vasyl LukiyanchukOncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf, 01309 Dresden, Germany.
Leoni A Kunz-SchughartOncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf, 01309 Dresden, Germany.ORCID 0000-0003-3912-6594
Anna DubrovskaOncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf, 01309 Dresden, Germany.ORCID 0000-0002-3375-1500
Oleh StasykDepartment of Cell Signaling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str. 14/16, 79005 Lviv, Ukraine.ORCID 0000-0001-8135-6102

Funding

Federal Ministry of Education and Research I-DRUG: The German Ukrainian Radiosensitizer Development Initiative, 0124U003964German Cancer Aid 70114659NRFU N 2023.04/0048Presidential Discretionary-Ukraine Support Grants, Simons Foundation Award No 1030281
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ArginineDrug Resistance, NeoplasmHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckCell AdhesionCell Line, TumorCell MovementCell ProliferationCell SurvivalDNA Breaks, Double-StrandedDNA RepairEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansPhenotypeRadiation ToleranceArginineacquired drug resistancearginine deprivation therapyDNA repairepithelial–mesenchymal transitionhead and neck squamous cell carcinomaradiosensitizationrecombinant human arginase type 1

Identifiers

PMID40563540
PMCPMC12190576

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.