Evidence map›Paper›PMID 40563763›Full record

ArticleBrain sciences2025

The Relationship Between Autoimmune Disorders and Multiple Sclerosis: Clinical Insights and Therapeutic Approaches.

Magdalena Iwan, Weronika Wójtowicz, Jakub Milczarek, Natalia Wyroba, Zuzanna Wydrych, Olga Falger, Michalina Rzepka, Tomasz Chmiela, Mateusz Toś, Joanna Siuda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Magdalena IwanStudents' Scientific Association, Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.ORCID 0009-0000-0385-0877
Weronika WójtowiczStudents' Scientific Association, Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.ORCID 0009-0001-7006-3926
Jakub MilczarekStudents' Scientific Association, Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.ORCID 0000-0002-4099-0999
Natalia WyrobaStudents' Scientific Association, Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.ORCID 0009-0004-2230-6403
Zuzanna WydrychStudents' Scientific Association, Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Olga FalgerStudents' Scientific Association, Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Michalina RzepkaDepartment of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 14 Street, 40-752 Katowice, Poland.
Tomasz ChmielaDepartment of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 14 Street, 40-752 Katowice, Poland.ORCID 0000-0001-6022-7731
Mateusz TośDepartment of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 14 Street, 40-752 Katowice, Poland.ORCID 0000-0003-3693-9565
Joanna SiudaDepartment of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 14 Street, 40-752 Katowice, Poland.ORCID 0000-0002-0340-660X

Funding

Medical University of Silesia KKN/2110/5/2025
6 · The paper itself

Abstract

backgroundMultiple sclerosis (MS) and autoimmune diseases (AIDs) share immunological underpinnings, leading to frequent co-occurrence. This study investigated the prevalence of AIDs among Polish patients with MS (PwMSs) and its potential effects on disease characteristics. The aims were to compare clinical and demographic characteristics between PwMSs with and without coexisting AIDs.

methodsA retrospective analysis was conducted on data from 580 PwMSs who were treated at the Department of Neurology, University Clinical Center in Katowice, Poland, between February 2018 and August 2023. Variables analyzed included age, sex, MS type, disease duration, treatment, Expanded Disability Status Scale (EDSS) scores, thyroid-stimulating hormone (TSH), and vitamin D3 serum concentrations.

resultsAID was identified in 16.9% of PwMSs (n = 98). Compared with PwMSs without AIDs, PwMSs with AIDs exhibited significantly higher mean age (44.61 ± 11.40 vs. 42.24 ± 12.27 years;

conclusionsPwMSs with AIDs exhibit distinct characteristics, including older age, increased disease duration, and greater disability. Thyroid disorders are notably the most prevalent AIDs among PwMSs. These findings underscore the intricate interplay between AIDs and MS and highlight the necessity for further research into their long-term impact.

Indexed as

autoimmune diseasesmultiple sclerosisthyroid disease

Identifiers

PMID40563763
PMCPMC12191017

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.