Evidence map›Paper›PMID 40564018›Full record

ArticleBiomedicines2025

Phospholipid-Rich DC-Vesicles with Preserved Immune Fingerprints: A Stable and Scalable Platform for Precision Immunotherapy.

Ramon Gutierrez-Sandoval, Francisco Gutierrez-Castro, Natalia Muñoz-Godoy, Ider Rivadeneira, Adolay Sobarzo, Luis Alarcón, Wilson Dorado, Andy Lagos, Diego Montenegro, Ignacio Muñoz and 5 more

Abstract read
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ramon Gutierrez-SandovalDepartment of Oncopathology, OGRD Alliance, Lewes, DE 19958, USA.ORCID 0009-0004-8428-9549
Francisco Gutierrez-CastroDepartment of Cancer Research, Flowinmunocell-Bioexocell Group, 08028 Barcelona, Spain.
Natalia Muñoz-GodoyDepartment of Cancer Research, Flowinmunocell-Bioexocell Group, 08028 Barcelona, Spain.
Ider RivadeneiraDepartment of Outreach and Engagement Programs for OGRD Consortium, Charlestown KN0802, Saint Kitts and Nevis.
Adolay SobarzoDepartmento de Ciencias Biológicas y Químicas, Facultad de Medicina y Ciencia, Universidad San Sebastián, Concepción 4080871, Chile
Luis AlarcónDepartment of Outreach and Engagement Programs for OGRD Consortium, Charlestown KN0802, Saint Kitts and Nevis.
Wilson DoradoDepartment of Outreach and Engagement Programs for OGRD Consortium, Charlestown KN0802, Saint Kitts and Nevis.
Andy LagosDepartment of Outreach and Engagement Programs for OGRD Consortium, Charlestown KN0802, Saint Kitts and Nevis.
Diego MontenegroDepartment of Outreach and Engagement Programs for OGRD Consortium, Charlestown KN0802, Saint Kitts and Nevis.
Ignacio MuñozDepartment of Outreach and Engagement Programs for OGRD Consortium, Charlestown KN0802, Saint Kitts and Nevis.
Rodrigo AguileraDepartment of Outreach and Engagement Programs for OGRD Consortium, Charlestown KN0802, Saint Kitts and Nevis.
Jordan IturraDepartment of Outreach and Engagement Programs for OGRD Consortium, Charlestown KN0802, Saint Kitts and Nevis.
Francisco KrakowiakDepartment of Molecular Oncopathology, Bioclas, Concepcion 4030000, Chile.
Cristián Peña-VargasDepartment of Oncopathology, OGRD Alliance, Lewes, DE 19958, USA.
Andres ToledoDepartment of Oncopathology, OGRD Alliance, Lewes, DE 19958, USA.

Funding

Fundación Biotech FB-20222-0871
6 · The paper itself

Abstract

Despite the progress in cancer immunotherapy, therapeutic responses in solid tumors remain suboptimal due to the immunosuppressive nature of the tumor microenvironment (TME), limited immune cell infiltration, and inefficient delivery of immune-activating agents. Dendritic cell-based therapies possess strong immunological potential but face challenges in viability, standardization, and scalability. Likewise, exosomes and CAR-T cells are hindered by instability, production complexity, and limited efficacy in immune-excluded tumor settings.

Indexed as

cytokine modulationdendritic cell vesiclesimmune fingerprintingimmune modulationlyophilization stabilityNon-New Chemical Entities (NCEs)phospholipid-rich vesiclesproteomic analysistumor microenvironment

Identifiers

PMID40564018
PMCPMC12189087

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.