Evidence mapPaperPMID 40564171Full record

ReviewBiomedicines2025

Emerging Chemotherapy Targets: Insights from Advances in Glioma Treatment.

Rogina Rezk, Abanob George Hanna, Hunter Hutchinson, Mariam Farag, Brandon Lucke-Wold

Abstract readReview
In one paragraph

Review in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rogina RezkCollege of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0009-0006-4295-877X
Abanob George HannaCollege of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0009-0001-0679-0942
Hunter HutchinsonCollege of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0009-0005-3202-3949
Mariam FaragCollege of Medicine, University of Florida, Gainesville, FL 32610, USA.
Brandon Lucke-WoldDepartment of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.ORCID 0000-0001-6577-4080

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary brain tumors represent a significant focus of contemporary research. With advancements in technology and the increasing detection of cases through novel diagnostic methods, innovative therapies and approaches to chemotherapy continue to emerge. The paper explores recent advancements in chemotherapy for glioblastoma, highlighting innovative approaches that provide valuable mechanistic insights. It delves into the mechanisms of action, molecular targets, and the future potential of emerging therapies for gliomas. Additionally, this paper offers an overview investigating a range of therapies, including various chemotherapeutic agents, CAR-T cell therapies, drugs targeting cellular respiration, and other approaches. Furthermore, the paper addresses chemotherapy-related challenges, including the blood-brain barrier, drug resistance, and immunosuppression, while proposing potential solutions to overcome these obstacles.

Indexed as

blood–brain barrierglioblastomagliomaimmunosuppressionprimary brain tumorstumor blood–brain barrier

Identifiers

PMID40564171
PMCPMC12190830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.