Evidence mapPaperPMID 40564182Full record

ReviewBiomedicines2025

Heart Failure and Wide QRS: Clinical and Pharmacological Perspectives.

Alfredo Mauriello, Adriana Correra, Gerardo Elia Del Vecchio, Martina Grieco, Arianna Amata, Pierpaolo Di Micco, Egidio Imbalzano, Mariano Paternoster, Antonia Ascrizzi, Vincenzo Quagliariello and 4 more

Abstract readReview
In one paragraph

Review in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alfredo MaurielloS.C. Cardiologia, Istituto Nazionale Tumori, IRCCS, Fondazione "G. Pascale", 80131 Naples, Italy.ORCID 0000-0001-7060-6938
Adriana CorreraIntensive Cardiac Care Unit, San Giuseppe Moscati Hospital, ASL Caserta, 81031 Aversa, Italy.
Gerardo Elia Del VecchioCardiology Unit, "A. Guerriero" Hospital, ASL Caserta, 81025 Marcianise, Italy.
Martina GriecoCardiology Unit, S. Giovanni Bosco Hospital, ASL Napoli 1, 80100 Naples, Italy.
Arianna AmataDepartment of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy.
Pierpaolo Di MiccoDepartment of Medicine, Buon Consiglio Fatebenefratelli Hospital of Naples, 80122 Naples, Italy.ORCID 0000-0002-8484-4598
Egidio ImbalzanoDipartimento Di Clinica Medica E Farmacologia, University of Messina, 98100 Messina, Italy.ORCID 0000-0003-2656-5467
Mariano PaternosterDepartment of Advanced Biomedical Sciences, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.
Antonia AscrizziCardiology Unit, Department of Medical and Translational Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 80131 Naples, Italy.
Vincenzo QuagliarielloS.C. Cardiologia, Istituto Nazionale Tumori, IRCCS, Fondazione "G. Pascale", 80131 Naples, Italy.
Nicola MaureaS.C. Cardiologia, Istituto Nazionale Tumori, IRCCS, Fondazione "G. Pascale", 80131 Naples, Italy.ORCID 0000-0003-3704-0092
Francesco GiallauriaDepartment of Translational Medical Sciences, "Federico II" University of Naples, Via S. Pansini 5, 80131 Naples, Italy.ORCID 0000-0003-4119-9397
Antonello D'AndreaCardiology and Intensive Care Unit, Department of Cardiology, Umberto I Hospital, 84014 Nocera Inferiore, Italy.ORCID 0000-0002-9698-9145
Vincenzo RussoCardiology Unit, Department of Medical and Translational Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 80131 Naples, Italy.ORCID 0000-0002-9227-0360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure (HF) is a highly prevalent cardiovascular clinical syndrome. Health care spending on HF treatment is high. Therefore, its treatment has generated a great deal of interest in pharmacological research in recent years. Recent guidelines have introduced several molecules for the treatment of HF that have demonstrated safety, and above all, efficacy. One of the worst aspects of HF is ventricular dyssynchrony (VD) with a wide QRS interval. Currently, the cornerstone of VD therapy is cardiac resynchronization therapy (CRT). Our comprehensive review aims to analyze the effects of new molecules on QRS width and understand whether these molecules can provide benefits.

Indexed as

cardiac remodelingdapagliflozinempagliflozinheart failureQRS wideningsacubitril/valsartanventricular dyssynchronyvericiguat

Identifiers

PMID40564182
PMCPMC12190266

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.