Evidence mapPaperPMID 40564966Full record

ArticleInternational journal of molecular sciences2025

Sodium-Glucose Cotransporter 2 and Glucose Levels Affect Clear Cell Renal Cell Carcinoma Progression.

Yujiro Nagata, Ikko Tomisaki, Hisami Aono, Nguyen Thu Quynh, Eiji Kashiwagi, Naohiro Fujimoto

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yujiro NagataDepartment of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.ORCID 0000-0001-6815-4266
Ikko TomisakiDepartment of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Hisami AonoDepartment of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Nguyen Thu QuynhDepartment of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.ORCID 0000-0001-7468-9718
Eiji KashiwagiDepartment of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Naohiro FujimotoDepartment of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

Funding

Japan Society for the Promotion of Science JP24K19662
6 · The paper itself

Abstract

The biological significance of sodium-glucose cotransporter 2 (SGLT2) in clear cell renal cell carcinoma (ccRCC) has yet to be elucidated. In this study, we aimed to determine the role of SGLT2 in ccRCC tumor progression. The human ccRCC line KMRC-1, which contains a von Hippel-Lindau (

Indexed as

Carcinoma, Renal CellGlucoseKidney NeoplasmsSodium-Glucose Transporter 2ApoptosisBenzhydryl CompoundsCell Line, TumorCell MovementCell ProliferationCell SurvivalDisease ProgressionGlucosidesHumansMutationSodium-Glucose Transporter 2 InhibitorsVon Hippel-Lindau Tumor Suppressor ProteinBenzhydryl CompoundsdapagliflozinGlucoseGlucosidesSLC5A2 protein, humanSodium-Glucose Transporter 2Sodium-Glucose Transporter 2 InhibitorsVHL protein, humanVon Hippel-Lindau Tumor Suppressor Proteinclear cell renal cell carcinomaglucoseSGLT2tumor progressionvon Hippel–Lindau gene

Identifiers

PMID40564966
PMCPMC12192661

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.