Evidence map›Paper›PMID 40564981›Full record

ReviewInternational journal of molecular sciences2025

ALDH2 Enzyme Deficiency in Diabetic Cardiomyopathy.

Yang-Wen Hsieh, An-Sheng Lee, Kuo-Tzu Sung, Xuan-Ren Chen, Hsin-Hung Lai, Yun-Fang Chen, Chen-Yen Chien, Hung-I Yeh, Che-Hong Chen, Chung-Lieh Hung

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yang-Wen HsiehDepartment of Medical Research, Mackay Memorial Hospital, Taipei City 104, Taiwan.ORCID 0000-0002-2709-1040
An-Sheng LeeDepartment of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.ORCID 0000-0001-8176-3269
Kuo-Tzu SungDepartment of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.
Xuan-Ren ChenGraduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei City 100, Taiwan.ORCID 0000-0001-5115-282X
Hsin-Hung LaiInstitute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei City 112, Taiwan.
Yun-Fang ChenDepartment of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.
Chen-Yen ChienDepartment of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.ORCID 0000-0002-9329-505X
Hung-I YehDepartment of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.
Che-Hong ChenDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Chung-Lieh HungDepartment of Medical Research, Mackay Memorial Hospital, Taipei City 104, Taiwan.ORCID 0000-0002-2858-3493

Funding

MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTIONR01AA011147 · STANFORD UNIVERSITY · 1996 to 2025
$2.8M
NIAAA NIH HHS R01 AA011147NIAAA NIH HHS R37 AA011147
6 · The paper itself

Abstract

Diabetic cardiomyopathy (DCM) is a significant complication of diabetes, particularly affecting East Asian populations with a high prevalence of the ALDH2*2 (

Indexed as

Aldehyde Dehydrogenase, MitochondrialDiabetic CardiomyopathiesAnimalsHumansOxidative StressAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanALDH2*2 carriersALDH2 activatorsALDH2 enzyme deficiencydiabetic cardiomyopathyEast Asian populationsSGLT2 inhibitors

Identifiers

PMID40564981
PMCPMC12193655

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.