Evidence map›Paper›PMID 40565163›Full record

ArticleInternational journal of molecular sciences2025

Bioprospecting for Anti-Kinetoplastid Drug Discovery from

Amani Omrani, Meriam Ben Youssef, Ines Sifaoui, Eduardo Hernández-Álvarez, María J Trujillo-Rodríguez, Montse Saura-Cayuela, Verónica Pino, Hichem Sebai, Isabel L Bazzocchi, Jacob Lorenzo-Morales and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amani OmraniInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.ORCID 0009-0001-6213-4835
Meriam Ben YoussefInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
Ines SifaouiInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
Eduardo Hernández-ÁlvarezInstituto Universitario de Bio-Orgánica Antonio González and Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.ORCID 0000-0002-4306-2696
María J Trujillo-RodríguezInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.ORCID 0000-0003-2153-0441
Montse Saura-CayuelaInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
Verónica PinoInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.ORCID 0000-0002-1698-5524
Hichem SebaiLaboratory of Functional Physiology and Valorization of Bio-Ressources, Higher Institute of Biotechnology of Beja, University of Jendouba, Beja 382-9000, Tunisia.ORCID 0000-0003-0131-1401
Isabel L BazzocchiInstituto Universitario de Bio-Orgánica Antonio González and Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
Jacob Lorenzo-MoralesInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
José E PiñeroInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.ORCID 0000-0001-6233-8224
Ignacio A JiménezInstituto Universitario de Bio-Orgánica Antonio González and Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.ORCID 0000-0002-0641-607X

Funding

Cabildo Insular de Tenerife 2023-2028 CC20230222, CABILDO.23Consorcio Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Ministerio de Sanidad, Madrid, Spain CB21/13/00100M.B.Y. and A.O. were funded by the University of Jendouba and ayudas para estancias de Tesis Doctorales en régimen de cotutela de la ULL- Santander. I.S. was funded by the Cabildo Insular de Tenerife 2023-2028 (CC20230222) and by the programa posdoctoral CC20230222Ministerio de Sanidad, Spanish Government project PID2022-136549OB-100 funded by MCIN/AEI/10.13039/501100011033/ FEDER, UE
6 · The paper itself

Abstract

Natural products have long been recognized as invaluable resources in drug discovery. Essential oils have attracted widespread attention due to their broad spectrum of biological activities. Herein, we report the anti-kinetoplastid activity of

Indexed as

Antiprotozoal AgentsDrug DiscoveryOils, VolatileVerbenaceaeAcyclic MonoterpenesAnimalsLeishmaniaPlant LeavesStructure-Activity RelationshipTrypanosoma cruziAcyclic MonoterpenesAntiprotozoal AgentscitralOils, VolatileAloysia citrodoraanti-kinetoplastid activitybioassay-guided fractionationchemical modificationessential oilmechanism of action

Identifiers

PMID40565163
PMCPMC12193109

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.