Evidence map›Paper›PMID 40565244›Full record

ArticleInternational journal of molecular sciences2025

Maternal Vascular Adaptation in High-Risk Pregnancies: Effects of Early Smoking Cessation on Hemodynamic and Endothelial Function.

Kaltrina Kutllovci Hasani, Mila Cervar-Zivkovic, Ursula Hiden, Adam Saloň, Manurishi Nanda, Bianca Steuber, Katharina Eberhard, Patrick De Boever, Christina Stern, Karoline Mayer-Pickel and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kaltrina Kutllovci HasaniDepartment of Obstetrics and Gynaecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.ORCID 0009-0004-2217-7074
Mila Cervar-ZivkovicDepartment of Obstetrics and Gynaecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.
Ursula HidenDepartment of Obstetrics and Gynaecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.ORCID 0000-0001-8009-020X
Adam SaloňVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Manurishi NandaDepartment of Obstetrics and Gynaecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.
Bianca SteuberGravitational Physiology and Aging Research Unit, Division of Physiology and Pathophysiology, Otto Löwi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Neue Stiftingtalstrasse 6/V, 8010 Graz, Austria.
Katharina EberhardCore Facility Computational Bioanalytic, ICAL University of Graz, Stiftingtalstraße 24/1, 8010 Graz, Austria.
Patrick De BoeverResearch, Innovation & Valorisation Antwerp (RIVA), Antwerp University Hospital, Campus Middelheim, Middelheimlaan 1, 2020 Antwerp, Belgium.ORCID 0000-0002-5197-8215
Christina SternDepartment of Obstetrics and Gynaecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.ORCID 0000-0002-6330-1236
Karoline Mayer-PickelDepartment of Obstetrics and Gynaecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.ORCID 0000-0002-3077-108X
Nandu GoswamiGravitational Physiology and Aging Research Unit, Division of Physiology and Pathophysiology, Otto Löwi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Neue Stiftingtalstrasse 6/V, 8010 Graz, Austria.ORCID 0000-0002-6704-0723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular adaptation is vital for a healthy pregnancy but may be impaired in women at high risk for preeclampsia (PE), a condition marked by endothelial dysfunction. Smoking may lower the PE risk but harms vessels, and the effects of early cessation remain unclear. This prospective cohort study assessed vascular changes in high-risk pregnancies and the potential influence of early smoking cessation. Of 110 women screened for PE in the first trimester, 43 were classified as high-risk: 18 former smokers and 25 lifelong non-smokers. Vascular assessments were performed at 11-16, 24-28, and 34-37 weeks of gestation. Parameters included the carotid-femoral pulse wave velocity (cfPWV), asymmetric dimethylarginine (ADMA), mean arterial pressure (MAP), systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), and retinal vessel calibers (central retinal arteriolar and venular equivalents (CRAE, CRVE)). Serum cotinine confirmed abstinence in former smokers. Across gestation, ADMA (

Indexed as

Adaptation, PhysiologicalEndothelium, VascularHemodynamicsPre-EclampsiaPregnancy, High-RiskSmoking CessationAdultArginineBlood PressureFemaleHeart RateHumansPregnancyProspective StudiesPulse Wave AnalysisSmokingArginineN,N-dimethylargininecardiovascular adaptationhigh-risk pregnancypreeclampsiasmoking cessationvascular function

Identifiers

PMID40565244
PMCPMC12193101

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.