Evidence map›Paper›PMID 40565289›Full record

ArticleInternational journal of molecular sciences2025

Dysregulation of Inositol Polyphosphate 5-Phosphatase OCRL in Alzheimer's Disease: Implications for Autophagy Dysfunction.

Kunie Ando, May Thazin Htut, Eugenia Maria Antonelli, Andreea-Claudia Kosa, Lidia Lopez-Gutierrez, Carolina Quintanilla-Sánchez, Emmanuel Aydin, Emilie Doeraene, Siranjeevi Nagaraj, Ana Raquel Ramos and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Cells · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kunie AndoAlzheimer and Other Tauopathies Research Group, ULB Neuroscience Institute (UNI), ULB Center for Diabetes Research (UCDR), Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.ORCID 0000-0003-3822-175X
May Thazin HtutAlzheimer and Other Tauopathies Research Group, ULB Neuroscience Institute (UNI), ULB Center for Diabetes Research (UCDR), Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.
Eugenia Maria AntonelliAlzheimer and Other Tauopathies Research Group, ULB Neuroscience Institute (UNI), ULB Center for Diabetes Research (UCDR), Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.
Andreea-Claudia KosaAlzheimer and Other Tauopathies Research Group, ULB Neuroscience Institute (UNI), ULB Center for Diabetes Research (UCDR), Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.
Lidia Lopez-GutierrezAlzheimer and Other Tauopathies Research Group, ULB Neuroscience Institute (UNI), ULB Center for Diabetes Research (UCDR), Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.ORCID 0000-0001-7631-0505
Carolina Quintanilla-SánchezAlzheimer and Other Tauopathies Research Group, ULB Neuroscience Institute (UNI), ULB Center for Diabetes Research (UCDR), Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.
Emmanuel AydinAlzheimer and Other Tauopathies Research Group, ULB Neuroscience Institute (UNI), ULB Center for Diabetes Research (UCDR), Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.
Emilie DoeraeneAlzheimer and Other Tauopathies Research Group, ULB Neuroscience Institute (UNI), ULB Center for Diabetes Research (UCDR), Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.
Siranjeevi NagarajAlzheimer and Other Tauopathies Research Group, ULB Neuroscience Institute (UNI), ULB Center for Diabetes Research (UCDR), Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.
Ana Raquel RamosIRIBHM-Jacques E. Dumont, Campus Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Katia CoulonvalIRIBHM-Jacques E. Dumont, Campus Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium.ORCID 0000-0003-3799-569X
Pierre P RogerIRIBHM-Jacques E. Dumont, Campus Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Jean-Pierre BrionAlzheimer and Other Tauopathies Research Group, ULB Neuroscience Institute (UNI), ULB Center for Diabetes Research (UCDR), Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.ORCID 0000-0002-1917-775X
Karelle LeroyAlzheimer and Other Tauopathies Research Group, ULB Neuroscience Institute (UNI), ULB Center for Diabetes Research (UCDR), Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.ORCID 0000-0002-8661-5262

Funding

The IU/JAX Alzheimer's Disease Precision Models Center: Rat F344U54AG054345 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Gareth R Howell · 2016 to 2026
$95.6M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITEU24AG041689 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2012 to 2026
$42.3M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
Pathway discovery, validation and compound identification for Alzheimer's disease - SupplementU01AG046152 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2013 to 2017
$13.6M
Characterizing the Behavior Profile of Healthy Cognitive AgingR01AG034374 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PATRICIA A BOYLE · 2009 to 2026
$8.8M
Exploring the Role of the Brain Epigenome: Cognitive Decline and Life ExperiencesR01AG036042 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2009 to 2013
$4.1M
Exploring the Role of the Brain Transcriptome in Cognitive DeclineR01AG036836 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI DE JAGER, PHILIP L · 2011 to 2014
$2.9M
Targeted Proteomics of Resilient Cognition in AgingR01AG039478 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ARNOLD, STEVEN E · 2011 to 2015
$2.5M
The Clinical Profile of Parkinson's Disease (PD) PathologyR01NS078009 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI BUCHMAN, ARON S · 2012 to 2016
$2.4M
Belgian FRS-FNRS NAFondation Médicale Reine Elisabeth NANIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG034374NIA NIH HHS R01 AG034504NIA NIH HHS R01 AG036042NIA NIH HHS R01 AG036836NIA NIH HHS R01 AG039478NIA NIH HHS R01 AG041232NIA NIH HHS R01 AG042210NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG046152NIA NIH HHS U24 AG041689NIA NIH HHS U54 AG054345NINDS NIH HHS R01 NS078009NINDS NIH HHS U18 NS082140the Academic Medical Interdisciplinary Research (AMIR) Foundation NAthe Belgian Fondation Recherche Alzheimer/ Stichting Alzheimer Onderzoek NAthe Belgian Fonds de la Recherche Scientifique Médicale T.0023.15the Fund Aline (King Baudouin Foundation) NAthe ULB Génicot Fund NA
6 · The paper itself

Abstract

Autophagy is impaired in Alzheimer's disease (AD), particularly at the stage of autophagosome-lysosome fusion. Recent studies suggest that the inositol polyphosphate 5-phosphatase OCRL (Lowe oculocerebrorenal syndrome protein) is involved in this fusion process; however, its role in AD pathophysiology remains largely unclear. In this study, we investigated the localization and expression of OCRL in post-mortem AD brains and in a 5XFAD transgenic mouse model. While

Indexed as

Alzheimer DiseaseAutophagyPhosphoric Monoester HydrolasesAgedAged, 80 and overAnimalsBeclin-1BrainDisease Models, AnimalFemaleHumansMaleMiceMice, Transgenictau ProteinsBeclin-1OCRL protein, humanPhosphoric Monoester Hydrolasestau ProteinsAlzheimer’s diseaseamyloid ßautophagyBeclin1OCRLphosphatidylinositolpTautau

Identifiers

PMID40565289
PMCPMC12192959

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.