Evidence map›Paper›PMID 40565345›Full record

ArticleInternational journal of molecular sciences2025

Elucidating Regulatory Mechanisms of Genes Involved in Pathobiology of Sjögren's Disease: Immunostimulation Using a Cell Culture Model.

Daniel D Kepple, Thomas E Thornburg, Micaela F Beckman, Farah Bahrani Mougeot, Jean-Luc C Mougeot

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel D KeppleTranslational Research Laboratories, Department of Oral Medicine/Oral & Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.ORCID 0000-0003-0566-3623
Thomas E ThornburgTranslational Research Laboratories, Department of Oral Medicine/Oral & Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
Micaela F BeckmanTranslational Research Laboratories, Department of Oral Medicine/Oral & Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
Farah Bahrani MougeotTranslational Research Laboratories, Department of Oral Medicine/Oral & Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.ORCID 0000-0002-8903-333X
Jean-Luc C MougeotTranslational Research Laboratories, Department of Oral Medicine/Oral & Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.ORCID 0000-0002-8953-1769

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sjögren's disease (SjD) is an autoimmune disease of exocrine tissues. Prior research has shown that ETS proto-oncogene 1 (ETS1), STAT1, and IL33 may contribute to the disease's pathology. However, the regulatory mechanisms of these genes remain poorly characterized. Our objective was to explore the mechanisms of SjD pathology and to identify dysfunctional regulators of these genes by immunostimulation of SjD and

Indexed as

Gene Expression RegulationSjogren's SyndromeCell LineEpithelial CellsHumansInterferon-gammaInterleukin-33MicroRNAsPoly I-CProto-Oncogene MasProto-Oncogene Protein c-ets-1Salivary GlandsSTAT1 Transcription FactorETS1 protein, humanInterferon-gammaInterleukin-33MAS1 protein, humanMicroRNAsPoly I-CProto-Oncogene MasProto-Oncogene Protein c-ets-1STAT1 protein, humanSTAT1 Transcription FactorETS1gamma-IFNInterleukin-33iSGECmiRNApoly(I:C)regulationSjögren’s diseaseSTAT1

Identifiers

PMID40565345
PMCPMC12192667

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.