Evidence map›Paper›PMID 40565356›Full record

ArticleInternational journal of molecular sciences2025

Pro-Apoptotic Activity of 1-(4,5,6,7-Tetrabromo-1

Patrycja Wińska, Monika Wielechowska, Łukasz Milewski, Paweł Siedlecki, Edyta Łukowska-Chojnacka

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review of promising benzimidazole-based anticancer agents (2023-2026).Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Article
  3. Targeting G6PD with Benzimidazole and Thiazole Derivatives SuppressesInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Patrycja WińskaFaculty of Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664 Warsaw, Poland.
Monika WielechowskaFaculty of Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664 Warsaw, Poland.
Łukasz MilewskiInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego St. 5A, 02-106 Warsaw, Poland.
Paweł SiedleckiInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego St. 5A, 02-106 Warsaw, Poland.ORCID 0000-0002-7482-1341
Edyta Łukowska-ChojnackaFaculty of Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664 Warsaw, Poland.ORCID 0000-0002-9512-7404

Funding

Research was funded by (POB Biotechnology and biomedical engineering) of Warsaw University of Technology within the Excellence Initiative: Research University (IDUB) programme. LIDER POB BIB-2
6 · The paper itself

Abstract

Inhibition of CK2 and/or PIM-1 kinases has been shown to induce apoptosis in a variety of cancer cell lines, underscoring their potential as valuable targets in anti-cancer drug development. In this study, a series of

Indexed as

Antineoplastic AgentsApoptosisBenzimidazolesBreast NeoplasmsPrecursor Cell Lymphoblastic Leukemia-LymphomaProtein Kinase InhibitorsProto-Oncogene Proteins c-pim-1AnimalsCasein Kinase IICell Line, TumorCell ProliferationChlorocebus aethiopsFemaleHumansMCF-7 CellsMolecular Docking SimulationAntineoplastic AgentsBenzimidazolesCasein Kinase IIPIM1 protein, humanProtein Kinase InhibitorsProto-Oncogene Proteins c-pim-1anti-tumor activitybreast cancerleukemiaPIM kinaseprotein kinase CK2TBBi derivatives

Identifiers

PMID40565356
PMCPMC12193579

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.