Evidence mapPaperPMID 40565373Full record

ArticleInternational journal of molecular sciences2025

Melatonin Alleviates MBP-Induced Oxidative Stress and Apoptosis in TM3 Cells via the SIRT1/PGC-1α Signaling Pathway.

Jingjing Liu, Qingcan Guan, Shuang Li, Qi Qi, Xiaoyan Pan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jingjing LiuCenter for Reproductive Medicine, Jilin Medical University, Jilin 132013, China.
Qingcan GuanCenter for Reproductive Medicine, Jilin Medical University, Jilin 132013, China.
Shuang LiCenter for Reproductive Medicine, Jilin Medical University, Jilin 132013, China.
Qi QiCenter for Reproductive Medicine, Jilin Medical University, Jilin 132013, China.
Xiaoyan PanCenter for Reproductive Medicine, Jilin Medical University, Jilin 132013, China.

Funding

the Innovation and Entrepreneurship Training Program of Jilin Medical University 202413706004the Scientific and Technological Research Project of Jilin Province 20240305074YY
6 · The paper itself

Abstract

This study investigates the role of melatonin in alleviating the oxidative stress and apoptosis of TM3 Leydig cells induced by 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), the primary active metabolite of Bisphenol A, and clarifies its potential mechanisms involving the SIRT1/PGC-1α pathway. We found that melatonin effectively mitigated MBP-induced cytotoxicity in TM3 cells (

Indexed as

ApoptosisBenzhydryl CompoundsLeydig CellsMelatoninOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhenolsSignal TransductionSirtuin 1AnimalsAntioxidantsCell LineMaleMembrane Potential, MitochondrialMiceTestosteroneAntioxidantsBenzhydryl CompoundsMelatoninPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhenolsPpargc1a protein, mouseSirt1 protein, mouseSirtuin 1TestosteroneapoptosisMBPmelatoninoxidative stressTM3 cells

Identifiers

PMID40565373
PMCPMC12193403

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.