Evidence map›Paper›PMID 40566588›Full record

ArticleLife (Basel, Switzerland)2025

Exploring the Role of Diabetes in ALS: A Population-Based Cohort Study.

Ilaria Martinelli, Giulia Gianferrari, Rebecca Santarelli, Elisabetta Zucchi, Cecilia Simonini, Nicola Fini, Andrea Ghezzi, Annalisa Gessani, Laura Ferri, Krzysztof Smolik and 21 more

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Ilaria MartinelliDepartment of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41126 Modena, Italy.
Giulia GianferrariDepartment of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41126 Modena, Italy.ORCID 0000-0002-4260-0915
Rebecca SantarelliDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Elisabetta ZucchiDepartment of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41126 Modena, Italy.
Cecilia SimoniniDepartment of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41126 Modena, Italy.ORCID 0000-0001-5456-2365
Nicola FiniDepartment of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41126 Modena, Italy.
Andrea GhezziNeuroscience Ph.D. Program, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Annalisa GessaniDepartment of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41126 Modena, Italy.
Laura FerriNeuroscience Ph.D. Program, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0003-2105-5038
Krzysztof SmolikDepartment of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41126 Modena, Italy.
Diana FerraroDepartment of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41126 Modena, Italy.
Roberta BedinDepartment of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41126 Modena, Italy.ORCID 0000-0001-5006-3294
Matteo GizziDepartment of Neurology, Faenza and Ravenna Hospital, 48100 Ravenna, Italy.
Elisabetta SetteDepartment of Neurology, St. Anna Hospital, 44124 Ferrara, Italy.
Veria VacchianoIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.ORCID 0000-0002-3607-2394
Luigi BonanIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Lucia ZinnoDepartment of General and Specialized Medicine, University Hospital of Parma, 43126 Parma, Italy.
Patrizia De MassisDepartment of Neurology, Imola Hospital, 40026 Bologna, Italy.ORCID 0000-0001-9713-7721
Elena CanaliDepartment of Neurology, IRCCS Arcispedale Santa Maria Nuova, 42123 Reggio Emilia, Italy.
Doriana MediciDepartment of Neurology, Fidenza Hospital, 43036 Parma, Italy.
Emilio TerlizziDepartment of Neurology, G. Da Saliceto Hospital, 29121 Piacenza, Italy.
Simonetta MorresiDepartment of Neurology, Bufalini Hospital, 47521 Cesena, Italy.
Mario SantangeloDepartment of Neurology, Carpi Hospital, 41012 Modena, Italy.
Alberto PatuelliDepartment of Neurology, Forlì Hospital, 47121 Forlì, Italy.
Marco Currò DossiDepartment of Neurology, Faenza and Ravenna Hospital, 48100 Ravenna, Italy.
Marco LongoniDepartment of Neurology, Bufalini Hospital, 47521 Cesena, Italy.ORCID 0000-0003-2173-4858
Maura PugliattiDepartment of Neurosciences and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Tommaso FilippiniDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0003-2100-0344
Salvatore FerroDepartment of Hospital Services, Emilia Romagna Regional Health Authority, 40127 Bologna, Italy.
Errals Study Group
Jessica MandrioliDepartment of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41126 Modena, Italy.ORCID 0000-0002-9244-9782

Funding

The Emilia Romagna Registry for ALS (ERRALS) is supported by a grant from the Emilia Romagna Regional Health Authority GPG/2022/1343
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) as a comorbidity in amyotrophic lateral sclerosis (ALS) has sparked interest for its potential impact on disease expression and prognosis. In this retrospective cohort study, we investigated the prevalence and clinical correlates of T2DM in a large cohort of patients from the ALS registry of a Northern Italy region, Emilia Romagna, established in 2009. Out of 1756 ALS patients enrolled up to 2021, 145 were affected by T2DM (diALS). Patients with diALS were older than those without T2DM (ndALS) (71.56 vs. 65.76 years,

Indexed as

amyotrophic lateral sclerosisdiabetes mellitusdisease progressionmetabolismrespiratory dysfunctiontracheostomy

Identifiers

PMID40566588
PMCPMC12194302

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.